PMID: 11320057Apr 26, 2001Paper

Anticoagulant heparan sulfate proteoglycans expression in the rat ovary peaks in preovulatory granulosa cells

Glycobiology
Marc PrincivalleA I de Agostini

Abstract

Ovarian granulosa cells synthesize anticoagulant heparan sulfate proteoglycans (aHSPGs), which bind and activate antithrombin III. To determine if aHSPGs could contribute to the control of proteolytic activities involved in follicular development and ovulation, we studied the pattern of expression of these proteoglycans during the ovarian cycle. aHSPGs were localized on cells and tissues by (125)I-labeled antithrombin III binding followed by microscopic autoradiography. Localization of aHSPGs has shown that cultured granulosa cells, hormonally stimulated by gonadotropins to differentiate in vitro, up-regulate their synthesis and release of aHSPGS: In vivo, during gonadotropin-stimulated cycle, aHSPGs are present on granulosa cells of antral follicles and are strongly labeled in preovulatory follicles. These data demonstrate that aHSPG expression in the ovarian follicle is hormonally induced to culminate in preovulatory follicles. Moreover, we have shown that five heparan sulfate core proteins mRNA (perlecan; syndecan-1, -2, and -4; and glypican-1) are synthesized by granulosa cells, providing attachment for anticoagulant heparan sulfate chains on the cell surface and in the extracellular matrix. These core proteins are constant...Continue Reading

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Citations

Sep 15, 2005·Cell and Tissue Research·Helen F Irving-Rodgers, Raymond J Rodgers
Sep 23, 2010·Journal of Assisted Reproduction and Genetics·Tom AdriaenssensJohan Smitz
Jun 14, 2005·Biochimica Et Biophysica Acta·Junji OhnishiTakayuki Takahashi
Aug 2, 2008·The Journal of Biological Chemistry·Ariane I de AgostiniRobert J Linhardt
Jun 5, 2002·Annual Review of Biochemistry·Jeffrey D Esko, Scott B Selleck
Apr 3, 2003·The Journal of Clinical Investigation·Sassan HajMohammadiNicholas W Shworak
Jul 4, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Hannah G ClarkeRaymond J Rodgers
Nov 11, 2015·Journal of Assisted Reproduction and Genetics·Yaakov BentovRobert F Casper
Dec 31, 2002·Molecular Reproduction and Development·Julie BédardJacques G Lussier
May 19, 2011·Proteomics. Clinical Applications·Annalisa CastagnaDaniela Cecconi
Jul 31, 2013·British Journal of Pharmacology·Shuntaro Ikeda, Masayasu Yamada
Dec 24, 2013·Matrix Biology : Journal of the International Society for Matrix Biology·Bryan E ThackerJeffrey D Esko
Jul 9, 2010·Biology of Reproduction·David T Armstrong, Raymond J Rodgers
Mar 30, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Simon ColombeJérôme Levallet
May 11, 2013·Molecular Endocrinology·Agne Velthut-MeikasAndres Salumets

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