Anticoagulant-induced pseudothrombocytopenia occurring after transcatheter arterial embolization for hepatocellular carcinoma

Japanese Journal of Clinical Oncology
Takeshi YoshikawaKazuro Sugimura

Abstract

Pseudothrombocytopenia (PTCP) is the in vitro phenomenon of anticoagulant-activated platelet agglutination that results in spuriously low platelet counts. We report the case of a 65-year-old man with EDTA- and sodium citrate-dependent PTCP occurring after transcatheter arterial embolization (TAE) for hepatocellular carcinoma (HCC) due to hepatitis C cirrhosis. Invasion of the portal and hepatic veins by HCC formed severe trans-tumoral arterio-venous shunts that were effectively treated by TAE. Two days after the therapy, PTCP was seen on blood count and continued for 4 months. The patient received unnecessary treatment for disseminated intravascular coagulation (DIC) until the diagnosis of PTCP was established. PTCP is a rare complication but should be considered after TAE for HCC; lack of recognition may lead the physician to misdiagnosis and patient mismanagement.

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Citations

May 9, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe BanfiGiuseppe Lippi
Aug 13, 2014·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Indranil Chakrabarti
Jan 11, 2012·Revista Da Sociedade Brasileira De Medicina Tropical·José Roberto LambertucciIzabela Voieta
Feb 10, 2017·Interventional Medicine & Applied Science·Ferenc KovacsErzsebet Rigo
Feb 10, 2021·Journal of Clinical Medicine·Benjamin LardinoisFrançois Mullier

Related Concepts

Antibiotics, Cytotoxic
Indirect Thrombin Inhibitors
Blood Platelets
Disseminated Intravascular Coagulation
Edetic Acid, Sodium Salt
Embolization, Therapeutic
Hepatitis C
Liver Carcinoma
Fibrosis, Liver
Malignant Neoplasm of Liver

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