Anticoagulant-induced pseudothrombocytopenia occurring after transcatheter arterial embolization for hepatocellular carcinoma

Japanese Journal of Clinical Oncology
Takeshi YoshikawaKazuro Sugimura


Pseudothrombocytopenia (PTCP) is the in vitro phenomenon of anticoagulant-activated platelet agglutination that results in spuriously low platelet counts. We report the case of a 65-year-old man with EDTA- and sodium citrate-dependent PTCP occurring after transcatheter arterial embolization (TAE) for hepatocellular carcinoma (HCC) due to hepatitis C cirrhosis. Invasion of the portal and hepatic veins by HCC formed severe trans-tumoral arterio-venous shunts that were effectively treated by TAE. Two days after the therapy, PTCP was seen on blood count and continued for 4 months. The patient received unnecessary treatment for disseminated intravascular coagulation (DIC) until the diagnosis of PTCP was established. PTCP is a rare complication but should be considered after TAE for HCC; lack of recognition may lead the physician to misdiagnosis and patient mismanagement.


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Related Concepts

Antibiotics, Cytotoxic
Indirect Thrombin Inhibitors
Blood Platelets
Disseminated Intravascular Coagulation
Edetic Acid, Sodium Salt
Embolization, Therapeutic
Hepatitis C
Liver Carcinoma
Fibrosis, Liver
Malignant Neoplasm of Liver

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