Anticoagulant Micrurus venoms: Targets and neutralization

Toxicology Letters
Daniel DashevskyBryan G Fry

Abstract

Snakebite is a neglected tropical disease with a massive global burden of injury and death. The best current treatments, antivenoms, are plagued by a number of logistical issues that limit supply and access in remote or poor regions. We explore the anticoagulant properties of venoms from the genus Micrurus (coral snakes), which have been largely unstudied, as well as the effectiveness of antivenom and a small-molecule phospholipase inhibitor-varespladib-at counteracting these effects. Our in vitro results suggest that these venoms likely interfere with the formation or function of the prothrombinase complex. We find that the anticoagulant potency varies widely across the genus and is especially pronounced in M. laticollaris. This variation does not appear to correspond to previously described patterns regarding the relative expression of the three-finger toxin and phospholipase A2 (PLA2) toxin families within the venoms of this genus. The coral snake antivenom Coralmyn, is largely unable to ameliorate these effects except for M. ibiboboca. Varespladib on the other hand completely abolished the anticoagulant activity of every venom. This is consistent with the growing body of results showing that varespladib may be an effective ...Continue Reading

References

Nov 1, 1980·European Journal of Biochemistry·H M VerheijG H de Haas
Mar 17, 2004·Toxicon : Official Journal of the International Society on Toxinology·R Manjunatha Kini
Jan 25, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Alessandra L CecchiniAndreimar M Soares
Jun 1, 2005·Toxicon : Official Journal of the International Society on Toxinology·R Manjunatha Kini
May 20, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·Stephen R ManockDavid A Warrell
Jan 16, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·Margaret A O'LearyGeoffrey K Isbister
Dec 23, 2009·PLoS Neglected Tropical Diseases·Robert A HarrisonDavid G Lalloo
May 3, 2011·PLoS Neglected Tropical Diseases·Bijayeeni MohapatraUNKNOWN Million Death Study Collaborators
Aug 22, 2013·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·A WoodR Weisman
May 29, 2015·Critical Reviews in Biochemistry and Molecular Biology·Stephanie A SmithJames H Morrissey
Sep 24, 2015·PLoS Neglected Tropical Diseases·Abdulrazaq G HabibDavid A Warrell
Jan 26, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Fábio BucaretchiStephen Hyslop
Oct 30, 2016·Toxicon : Official Journal of the International Society on Toxinology·Bruno LomonteJuan J Calvete
Feb 24, 2017·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Carlos A CañasSantiago Castaño-Valencia
Jul 13, 2017·Revista Da Sociedade Brasileira De Medicina Tropical·Fabiana da Rocha OliveiraJorge Luis Lopez Lozano
Aug 2, 2017·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Callum ListerBryan G Fry
Jan 22, 2018·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Jonathan GoldenbergBryan G Fry
Jul 19, 2018·Lancet·Joshua LongbottomDavid M Pigott
Aug 2, 2018·Journal of Molecular Evolution·Kate BaumannBryan Fry
Aug 29, 2018·Toxicon : Official Journal of the International Society on Toxinology·Timoteo Olamendi-PortugalLourival D Possani
Mar 12, 2019·PLoS Neglected Tropical Diseases·María Carlina Castillo-BeltránFrancisco Javier Ruiz-Gómez
Mar 27, 2019·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Christina N ZdenekBryan G Fry
Apr 2, 2019·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Jordan DebonoBryan G Fry
May 24, 2019·Toxicon : Official Journal of the International Society on Toxinology·Ageane Mota da SilvaPaulo Sergio Bernarde
Dec 1, 2019·Toxicon : Official Journal of the International Society on Toxinology·Pedro Ferreira BisnetoIgor Luis Kaefer
Dec 4, 2019·PLoS Neglected Tropical Diseases·Carlos A Bravo-VegaMahmood Sasa
Jun 9, 2020·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Nicholas J YoungmanBryan G Fry

❮ Previous
Next ❯

Citations

Jun 25, 2021·Journal of Chemical Ecology·Caroline Fabri Bittencourt RodriguesBryan Grieg Fry

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
Nicholas J YoungmanBryan G Fry
Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Henrique Roman RamosPatrick Jack Spencer
© 2021 Meta ULC. All rights reserved