Anticoagulant therapy in pregnancy. Report of 54 cases

Acta Obstetricia Et Gynecologica Scandinavica
F LecuruR Taurelle

Abstract

To investigate the adverse effects of anticoagulant therapy during pregnancy in a tertiary care center. A prospective study was carried out between 1 January 1977 and 31 December 1994 and included 54 pregnancies in 50 women treated with anticoagulants. In Group I (n=43) oral anticoagulants were replaced for heparin from the sixth until the end of the twelfth week of gestation and acenocoumarol was not substituted. All patients received vitamin K antagonists during the second and third trimesters. Heparin was given after 36 weeks of pregnancy until the tenth day in the postpartum period. Statistical comparisons used Chi square test (with the Yates correction when appropriate) and Student t test. Mechanical heart valve prosthesis was the most frequent indication (68%). There was one artificial heart valve thrombosis during first trimester in Group I and none in Group II (p=0.45). One spontaneous abortion occurred in each group (p=0.86). Seven cardiac complications (13.7%) occurred during the second and third trimesters. We recorded no thrombotic episode of an artificial heart valve after the first trimester of pregnancy. Hemorrhagic complications occurred in mid-pregnancy (one case=2%) and during peripartum (eight cases=16%). Two...Continue Reading

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Citations

Feb 26, 2000·Fertility and Sterility·R B StrickerE E Winger
Oct 18, 2002·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·D Blickstein, I Blickstein
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Sep 1, 1997·Obstetrics and Gynecology Clinics of North America·L A Barbour

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