PMID: 16637458Apr 28, 2006Paper

Anticoagulant treatment failure

Vnitr̆ní lékar̆ství
A Buliková, M Penka

Abstract

Anticoagulant therapy includes unfractionated heparin and vitamin K antagonists' administration. In both of these two types of drugs a treatment failure could occur. Currently available anticoagulants have a numerous disadvantages which could be involved in causes of their malfunctioning. During every new event of the re-thrombosis it is necessary to analyse all circumstances which influence this unfavourable outcome. Firstly, cases during adequate and non-adequate therapy should be distinguished. Secondly, it is important to identify the reasons of the treatment failure. Cancer and/or antiphospholipid antibodies are the main causes of re-thrombosis during adequate therapy. The conditions, which could steer for to non-adequate anticoagulation are various, and their identification could be difficult. The most important thing in this process is the objective documentation of the re-thrombosis. More efficacious, safer, and easier to use anticoagulants are under development. Some of them could bring a problem solution for these patients who underwent anticoagulant treatment failure.

Related Concepts

Related Feeds

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.