Anticoagulant venom and mammalian secreted phospholipases A(2): protein- versus phospholipid-dependent mechanism of action

Haemostasis
C M MounierR M Kini

Abstract

Some venom and mammalian-secreted phospholipases A(2) (sPLA(2)) have been described to exert an anticoagulant effect. This review will discuss and compare phospholipid-dependent versus protein-dependent mechanisms of action of these sPLA(2) on the coagulation cascade. The importance of venom proteins, and of the study of their pharmacological effects, to explore the physiological functions of homologous mammalian proteins is also pointed out.

Citations

Aug 17, 2005·Journal of Thrombosis and Haemostasis : JTH·Q LuK J Clemetson
Apr 15, 2008·Annual Review of Biochemistry·Gérard Lambeau, Michael H Gelb
Apr 21, 2018·American Journal of Hematology·Elisabeth FarhatEmmanuel J Favaloro
Nov 17, 2020·Toxicology Letters·Daniel DashevskyBryan G Fry

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