Anticoagulation for Hypercoagulable Patients Associated with Complications after Large Cranioplasty Reconstruction

Plastic and Reconstructive Surgery
Eric W SankeyChad R Gordon

Abstract

Despite advancements in materials and techniques used for cranial reconstruction, complication rates following reconstructive cranioplasty remain significant. In this study, the authors assessed the association of perioperative anticoagulation use and/or a hypercoagulable state with minor (i.e., not requiring surgical intervention) and major (i.e., surgical intervention required) complications after reconstructive cranioplasty for large skull defects. A retrospective cohort review of 108 consecutive cranioplasties performed between 2011 and 2014 was conducted. A multiple logistic regression analysis was performed to identify the adjusted association between the predictor variables and complications. Twenty-three primary (21.3 percent) and 85 secondary (78.7 percent) cranioplasties were performed on 94 patients with a median age of 50 years (interquartile range, 38 to 63 years). Median full-thickness calvarial defect size was 154 cm (interquartile range, 104 to 230 cm). Eleven minor (10.2 percent) and 18 major postoperative complications (16.7 percent) occurred in 26 cases (24.1 percent). Multiple logistic regression analysis revealed that coagulation status (i.e., perioperative use of anticoagulation therapy or hypercoagulable ...Continue Reading

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Citations

Jul 31, 2018·Annals of Plastic Surgery·Grzegorz J KwiecienBrian R Gastman
Dec 12, 2018·The Journal of Craniofacial Surgery·Gabriel F SantiagoChad Gordon
Sep 4, 2019·The Journal of Craniofacial Surgery·Christina Marie PasickPeter J Taub
Aug 5, 2016·Neurosurgery·Kimberly AshayeriChad R Gordon

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