Anticoagulation for radiation-induced neurotoxicity revisited.

Journal of Neuro-oncology
Caroline HappoldFriederike Schmidt

Abstract

No effective treatment for delayed radiation-induced neurotoxicity has been established. Its natural course is highly variable, but spontaneous recovery has been well documented. Here we report our experience with therapeutic anticoagulation in patients with cerebral lesions (n = 3), cranial nerve lesions (n = 1) or myelopathy (n = 4) attributed to irradiation. Two of three patients with cerebral lesions and the patient with cranial nerve lesions showed a minor improvement of clinical symptoms. In contrast, none of the patients with radiation myelopathy improved. No patient suffered hemorrhage or other adverse effects of anticoagulation. Overall, anticoagulation therapy demonstrates only modest activity for delayed radiation-induced neurotoxicity in this small case series.

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Citations

Oct 22, 2010·Current Opinion in Neurology·Patrick RothMichael Weller
Oct 21, 2016·Journal of Neuro-oncology·N DreznerE I Hwang
Jul 17, 2010·Der Nervenarzt·U Herrlinger, J P Steinbach
Jun 9, 2012·Stereotactic and Functional Neurosurgery·Gazanfar RahmathullaGene H Barnett
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Nov 16, 2014·Current Treatment Options in Neurology·Maanasa IndaramMarc H Levin

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