Anticoagulation for the long term treatment of venous thromboembolism in patients with cancer

The Cochrane Database of Systematic Reviews
Elie A AklHolger J Schünemann

Abstract

Cancer increases the risk of thromboembolic events and the risk of recurrent thromboembolic events while on anticoagulation. To compare the efficacy and safety of low molecular weight heparin (LMWH) and oral anticoagulants (vitamin K antagonist (VKA) and ximelagatran) for the long term treatment of venous thromboembolism (VTE) in patients with cancer. A comprehensive search was undertaken including a January 2007 search of electronic databases; Cochrane Central Register of Controlled Trials (CENTRAL), (The Cochrane Library 2007, Issue 1). MEDLINE (1966 onwards; accessed via OVID), EMBASE (1980 onwards; accessed via OVID) and ISI the Web of Science. Hand search of the proceedings of the American Society of Clinical Oncology and of the American Society of Hematology. Checking of references of included studies, relevant papers and related systematic reviews. Use of "related article" feature in PubMed; and (5) search of ISI the Web of Science for papers citing landmark studies. Randomized controlled trials (RCTs) comparing long term treatment with LMWH versus oral anticoagulants (VKA or ximelagatran) in patients with cancer and symptomatic objectively confirmed VTE. Using a standardized data form we extracted data on methodological...Continue Reading

Citations

Nov 26, 2009·Journal of Palliative Medicine·Wendy G Anderson, Nathan E Goldstein
Sep 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alok A KhoranaGary H Lyman
Jan 15, 2011·Cardiology Research and Practice·Ali ZalpourSyed Wamique Yusuf
Nov 9, 2015·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Lauren McCormackPaula Rausch
Jun 20, 2018·The Cochrane Database of Systematic Reviews·Lara A KahaleElie A Akl
Dec 17, 2009·Hematology·Brett L Cucchiara
Jan 29, 2011·Journal of Thrombosis and Thrombolysis·Andrea Lee, Mark Crowther
Oct 6, 2011·Hämostaseologie·A Falanga, L Russo

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