PMID: 98317Jun 1, 1978

Anticonvulsant action of a 1,5-benzodiazepine, clobazam, in reflex epilepsy

A G ChapmanB S Meldrum


Clobazam, an anxiolytic 1,5-benzodiazepine, has been evaluated as an anticonvulsant in 2 animal models. In mice showing sound induced seizures, clobazam, 1--4 mg/kg, i.p., blocked seizure responses for 1--2 hr. In Senegalese baboons Papio papio showing photically induced myoclonus or seizures, clobazam, 2--12 mg/kg, i.v., totally prevented such responses for up to 6 hr. In baboons pretreated with allylglycine, 170--185 mg/kg, a similar but briefer protection was induced by clobazam. Neurological toxicity was not prominent (transient, slight nystagmus after clobazam, 2--6 mg/kg; muscular hypotonia after clobazam, 12 mg/kg). The possibility that 1,5-benzodiazepines are superior to 1,4-benzodiazepines in the therapy of epilepsy requires clinical investigation.


Oct 1, 1977·British Journal of Clinical Pharmacology·I HindmarchA J Hewett
May 1, 1975·Archives of Neurology·B S MeldrumP A Toseland
May 1, 1976·Archives of Neurology·T R Browne
Jun 1, 1967·Electroencephalography and Clinical Neurophysiology·K F KillamR Naquet


Sep 1, 1996·General Pharmacology·G De SarroA De Sarro
Jan 1, 1987·Journal of Pharmaceutical and Biomedical Analysis·M A AbounassifH Y Aboul-Enein
Mar 1, 1989·Epilepsy Research·N Senanayake
Jan 1, 1990·Epilepsy Research·N Senanayake
Jan 3, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Yu-Tze Ng, Stephen D Collins
Sep 1, 1997·Pharmacology, Biochemistry, and Behavior·G De SarroA De Sarro
Mar 1, 2003·Epilepsy & Behavior : E&B·Anthony L. RitaccioOrrin Devinsky
Jan 1, 1979·British Journal of Clinical Pharmacology·B S MeldrumR W Horton
Jan 28, 2009·Epilepsia·Joan A ConryJulie Stolle
Jun 1, 1994·Pharmacology & Toxicology·S Monjanel-MouterdeJ P Cano
Apr 16, 1983·British Medical Journal·J W AllenS S Jawad
Feb 1, 1992·Neuropharmacology·J D Wildin, B J Pleuvry
Mar 28, 2012·Expert Review of Neurotherapeutics·Hussam Seif-Eddeine, Yu-Tze Ng
Dec 12, 2012·Epilepsy Research·Melanie JennessonElizabeth A Thiele
Jan 1, 1982·Brain & Development·H ShimizuH Yabuuchi
Dec 1, 1983·British Journal of Clinical Pharmacology·B CenraudP Loiseau
Feb 1, 1980·The Journal of Pharmacy and Pharmacology·S CacciaS Garattini
May 21, 2013·Seizure : the Journal of the British Epilepsy Association·L John Greenfield
Mar 19, 2011·Seizure : the Journal of the British Epilepsy Association·J K A MillsW P Whitehouse
Dec 1, 1984·Epilepsia·U AgugliaH Gastaut
Sep 1, 1986·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·M I Arranz Peña, E Sanenz Lope

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