Anticonvulsant action of GABAB receptor positive modulator CGP7930 in immature rats

Epilepsy Research
Pavel Mares

Abstract

GABA(B) receptors mediate inhibition at early stages of development but mixed anti-and proconvulsant action of their agonists affecting all receptors was found in immature rats. Positive allosteric modulators of GABA(B) receptors potentiate only already active GABA(B) receptors and therefore more specific action is expected. Possible anticonvulsant action of CGP7930 was studied in a model of pentetrazol-induced seizures previously used for studies with agonists baclofen and SKF97541. Pentetrazol (100mg/kg) was administered subcutaneously in male rats 7, 12, 18, 25 and 90 days old pretreated with CGP7930 in doses 1-40 mg/kg i.p. High doses of CGP7930 suppressed generalized tonic-clonic seizures in all five age groups. Animals 18 and less days old exhibited a specific suppression of the tonic phase after lower doses of CGP7930. Twelve-day-old rats were the most sensitive to anticonvulsant effect of CGP7930 (even the 2-mg/kg dose suppressed the tonic phase whereas 20-mg/kg dose was active in other age groups). Minimal clonic seizures (mS) were moderately potentiated by low doses of CGP7930 in 18-day-old but suppressed by the highest dose in 25-day-old rats. The 60-mg/kg dose of PTZ induced only mS in 4 out of 9 25-day-old rats; th...Continue Reading

References

Nov 1, 1992·Naunyn-Schmiedeberg's Archives of Pharmacology·L VelisekR Schickerova
Nov 1, 1987·Epilepsy Research·C M Van RijnO R Hommes
Sep 1, 1987·Epilepsy Research·M Pohl, P Mares
Nov 1, 1970·American Journal of Diseases of Children·J Dobbing
Apr 1, 1983·British Journal of Pharmacology·B Ault, J V Nadler
Sep 1, 1994·Neuroscience·S M Turgeon, R L Albin
Oct 15, 1998·Molecular and Cellular Neurosciences·B MalitschekR Kuhn
Feb 27, 2004·Psychopharmacology·Maciej GasiorJeffrey M Witkin
Jul 14, 2005·Journal of Molecular Neuroscience : MN·Fiona H Marshall
Sep 1, 2007·Current Neuropharmacology·Jean-Philippe Pin, Laurent Prézeau
Jul 27, 2010·Advances in Pharmacology·Wolfgang Froestl
Jul 30, 2010·European Journal of Clinical Pharmacology·Mohamad KarouniCecilie Johannessen Landmark

❮ Previous
Next ❯

Citations

Dec 14, 2018·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Miho Terunuma
Jul 18, 2017·Pharmacology Research & Perspectives·Melody LiSteven Petrou
Nov 25, 2019·Epilepsy & Behavior : E&B·Pavel Mareš, Hana Kubová

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.