PMID: 108705Feb 28, 1979

Anticonvulsant activity in photosensitive baboons, Papio papio, of two new 1,5 benzodiazepines

Psychopharmacology
B S Meldrum, R W Horton

Abstract

Two new 1,5 benzodiazepines have been evaluated acutely as anticonvulsants in baboons, Papio papio, with photosensitive epilepsy. BAU 426 (8-Chlor-6-[2-chlorphenyl]-4H-s-triazolo-[4,3-a] [1,5-benzodiazepin-5-[6-H]on) and BAU 500 (analogue of BAU 426 with [2-trifluor methylphenyl] substituted for [2-chlorphenyl]), 0.1--5.0 mg/kg, were administered i.v. to baboons with and without priming with D,L allylglycine. BAU 426 or BAU 500, 0.1--0.2 mg/kg, produced partial or transient protection against photically induced myoclonus or epileptic responses. Complete protection, in the absence of signs of sedation or acute neurological toxicity, was seen 1--4 h after 0.5--2 mg/kg. EEG changes typical of benzodiazepines were seen for 1--3 h and clinical signs of sedation with some muscular hypotonia were evident for 1 h after either drug, 5 mg/kg. Clinical trials are required to determine if these compounds are superior to 1,4 benzodiazepines as anticonvulsants.

References

Oct 1, 1977·British Journal of Clinical Pharmacology·I HindmarchA J Hewett
May 1, 1975·Archives of Neurology·B S MeldrumP A Toseland
May 1, 1976·Archives of Neurology·T R Browne

Citations

Jan 3, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Yu-tze Ng, Stephen D Collins
Jan 1, 1979·British Journal of Clinical Pharmacology·B S MeldrumR W Horton
Jan 1, 1979·British Journal of Clinical Pharmacology·G W Hanks
Jan 1, 1982·Brain & Development·H ShimizuH Yabuuchi

Related Concepts

Metazoa
Anthropoidea
Anticonvulsants
Benzodiazepines
Dose-Response Relationship, Drug
Medicinal Plants Testing, Preclinical
Sedative Effect
Muscle Tonus
Papio
Photic Stimulation

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