PMID: 11311902Apr 20, 2001Paper

Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice

Neuropharmacology
R X MoldrichB S Meldrum

Abstract

The 3,4-dicarboxyphenylglycines (3,4-DCPG) inhibit sound-induced seizures in DBA/2 mice with the racemate being notably more potent than either isomer (ED(50) (nmol, i.c.v.)): (RS)-3,4-DCPG (0.004; 86 mg/kg, i.p.)>the mGlu(8) agonist (S)-3,4-DCPG (0.11)>the AMPA antagonist (R)-3,4-DCPG (0.38). A potentiation of anticonvulsant activity between AMPA and mGlu(8) receptors was confirmed by combining (R)-3,4-DCPG with the mGlu(8) agonist (RS)-4-phosphonophenylglycine. This potentiating mechanism provides a novel strategy for the treatment of epileptic seizures.

Citations

Feb 26, 2005·Psychopharmacology·James N C Kew, John A Kemp
Sep 12, 2002·European Journal of Pharmacology·Giovambattista De SarroBrian S Meldrum
Sep 13, 2003·European Journal of Pharmacology·Randal X MoldrichBrian S Meldrum
Dec 24, 2013·Pharmacology & Therapeutics·Lucyna Pomierny-ChamiołoMałgorzata Filip
Aug 26, 2014·Neurochemical Research·Marion S Mercier, David Lodge
Mar 14, 2014·Amino Acids·Enza PalazzoSabatino Maione
May 5, 2012·Biochemical Pharmacology·Peter J Flor, Francine C Acher
Apr 17, 2007·Brain Research·Melanie J RobbinsPeter R Maycox
Dec 4, 2003·British Journal of Pharmacology·Démetrius Antonio Machado AraújoJader Santos Cruz
Nov 15, 2013·Journal of Neurochemistry·Claire J Williams, David T Dexter
Jun 24, 2004·Bioorganic & Medicinal Chemistry·Silvina M TassoGuillermina L Estiú
Jun 22, 2006·Epilepsy Research·Georgia M Alexander, Dwayne W Godwin
Jun 19, 2019·Current Neuropharmacology·Serena BoccellaEnza Palazzo
Dec 4, 2016·Pharmacological Reports : PR·María CavasJosé Francisco Navarro

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