Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice

Epilepsy & Behavior : E&B
Pravinkumar BhutadaDharmendra R Mundhada

Abstract

Berberine, an isoquinoline alkaloid is reported to modulate several neurotransmitter systems like N-methyl-D-aspartate, nitric oxide and serotonin, which modulate convulsions. In addition, it is suggested that Berberis vulgaris may be useful in treatment of convulsion and epilepsy. Therefore, the present study investigated the effects of berberine in pentylenetetrazole, maximal electroshock (MES) and kainic acid (KA)-induced convulsions. The latency for development of convulsions and mortality rate was recorded in these models using mice. The results revealed that in MES-induced seizures model, berberine (10 and 20 mg/kg, i.p.) decreased duration of tonic hind limb extension and percent mortality. Moreover, these doses of berberine also protected mice against KA-induced clonic convulsions and decreased mortality. Berberine also protected mice against NMDA-induced turning behavior. Further, the anticonvulsant doses of berberine did not show any signs of motor in-coordination when tested in rotarod test. In conclusion, berberine exhibits anticonvulsant activity by modulating neurotransmitter systems and may find clinical application.

References

Dec 1, 1970·Japanese Journal of Pharmacology·S M ShanbhagB B Gaitonde
Feb 5, 2000·The New England Journal of Medicine·P Kwan, M J Brodie
Sep 20, 2001·Current Medicinal Chemistry·B K Kohl, G Dannhardt
Dec 25, 2003·Lancet Neurology·Steven C Schachter
Jul 5, 2005·Journal of Ethnopharmacology·Mohammad FatehiSamaneh Davodi
Jan 11, 2007·Journal of Neurochemistry·Gyorgy BagdyRita Jakus
Aug 10, 2007·BMC Complementary and Alternative Medicine·Marjan Nassiri-AslFarzaneh Zamansoltani
Mar 1, 2008·Journal of Ethnopharmacology·Muhammad NisarHumera Perveen
Jul 1, 2008·European Journal of Pharmacology·Shrinivas K Kulkarni, Ashish Dhir
Jul 12, 2008·Phytotherapy Research : PTR·Mohsen Imanshahidi, Hossein Hosseinzadeh
Jan 24, 2009·Epilepsy & Behavior : E&B·E Ngo BumS V Rakotonirina
Apr 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Steven C Schachter
Nov 26, 2009·Epilepsy & Behavior : E&B·Bruce HermannJoyce A Cramer
Dec 10, 2009·Phytotherapy Research : PTR·S K Kulkarni, Ashish Dhir

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Citations

Apr 24, 2014·Journal of Ethnopharmacology·Ben A ChindoAxel Becker
May 4, 2013·Metabolic Brain Disease·Hamid Kalalian MoghaddamAbdolaziz Ronaghi
Sep 26, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Jayant SanchetiSadhana Sathaye
Dec 5, 2013·Epilepsia·Hui-Ling ZhuPeng Li
May 24, 2012·European Journal of Pharmacology·Kotamballi N Chidambara MurthyBhimanagouda S Patil
Jul 26, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Jianming GuoYi You
Aug 18, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Pravinkumar BhutadaDharmendra Mundhada
Jun 29, 2010·Pharmacology, Biochemistry, and Behavior·Pravinkumar S BhutadaDharmendra R Mundhada
Jun 16, 2015·Epilepsy & Behavior : E&B·Nikolaus J Sucher, Maria C Carles
Dec 3, 2014·Neuroscience Letters·Lina Clara Gayoso e Almendra Ibiapina MorenoRivelilson Mendes Freitas
Nov 22, 2014·Neurological Research·Saeed MehrzadiHabib Ghaznavi
Aug 20, 2015·Saudi Journal of Biological Sciences·Mohamed A DkhilNoory T Taib
Jun 21, 2015·European Journal of Pharmacology·Anil KumarDinesh K Dhull
Feb 26, 2013·Journal of Acupuncture and Meridian Studies·Hossein HosseinzadehElahe Taghiabadi
Aug 27, 2016·International Journal of Preventive Medicine·Amir RashidianSeyed Mahdi Rezayat
Jan 7, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Reza SedaghatMehrdad Roghani
Jun 7, 2017·Journal of Evidence-based Complementary & Alternative Medicine·Amir RashidianSeyed Mahdi Rezayat
Aug 25, 2010·Phytotherapy Research : PTR·Pravinkumar BhutadaDharmendra Mundhada
Feb 28, 2019·Journal of Epilepsy Research·Vaishali GunaAmitava Chakrabarti
Jun 20, 2020·Cellular and Molecular Neurobiology·Zatollah AsemiOmid Reza Tamtaji
May 8, 2018·Phytotherapy Research : PTR·Xiaorui Lin, Nan Zhang
Jul 22, 2019·Journal of Basic and Clinical Physiology and Pharmacology·Praveen K KodumuriAnil Kumar Pandey
Nov 10, 2020·Journal of Ethnopharmacology·Jaskiran KaurNavneet Khurana
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohammad Amin AtazadeganAmirhossein Sahebkar
Jun 14, 2021·Neurochemical Research·Javad Sharifi-RadDaniela Calina
Apr 22, 2021·CNS & Neurological Disorders Drug Targets·Himanshi Varshney, Yasir Hasan Siddique
Nov 11, 2021·Journal of the American College of Nutrition·Jasleen BhasinVikas Chopra

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