Anticonvulsant activity of phenobarbital and valproate against maximal electroshock in mice during chronic treatment with caffeine and caffeine discontinuation

Epilepsia
M GasiorS J Czuczwar

Abstract

We evaluated the protective activity (expressed as ED50 values in mg/kg of phenobarbital (PB, 120 min before testing) and valproate (30 min) alone or combined with caffeine in male mice with seizures induced by maximal electroshock (MES). Both antiepileptic drugs (AEDs) were administered by intraperitoneal (i.p.) injection in a single dose to mice receiving intraperitoneal caffeine either in a single dose 30 min before the test or as pretreatment every 12 h for 3 and 14 days. In addition, we determined the ED50 values of the AEDs 24 and 72 h after 14-day treatment with caffeine. Finally, we studied the influence of a challenge dose of caffeine, injected in mice 24 and 72 h after 14 days of treatment with caffeine, on the protective activity of PB or VPA. Caffeine in a single dose of 23.1 mg/kg reduced the anticonvulsant effect of PB. Its protective activity was further impaired after 3 and 14 days of caffeine treatment. The ED50 for VPA was significantly increased both by the single dose of caffeine and by chronic treatment. The anticonvulsant activity of PB and VPA measured 24 and 72 h after 14-day treatment with caffeine did not differ from control values, but a challenge dose of caffeine injected 24 or 72 h after daily injec...Continue Reading

References

Jun 1, 1975·Annals of Internal Medicine·C W ZwillichM M Weinberger
Sep 1, 1975·Neurology·P R Yarnell, N S Chu
Dec 15, 1987·European Journal of Pharmacology·S J CzuczwarZ Kleinrok
Jan 1, 1988·Psychopharmacology·R R Griffiths, P P Woodson
Dec 1, 1974·Epilepsia·M S Schwartz, D F Scott
Oct 30, 1982·Lancet·J M SmithV Marks
Feb 1, 1981·Epilepsia·N S Chu
Oct 5, 1994·JAMA : the Journal of the American Medical Association·E C StrainR R Griffiths
Dec 15, 1993·Annals of Internal Medicine·M Shannon

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Citations

May 28, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Mariusz SwiaderStanisław J Czuczwar
Sep 19, 2003·Pharmacology, Biochemistry, and Behavior·Mariusz SwiaderStanisław J Czuczwar
Sep 12, 2003·Seizure : the Journal of the British Epilepsy Association·Kenneth R Kaufman, Rajesh C Sachdeo
May 23, 2014·Expert Opinion on Drug Metabolism & Toxicology·Magdalena Chrościńska-KrawczykStanisław J Czuczwar
Nov 9, 2011·Seminars in Pediatric Neurology·Phillip L PearlJoan A Conry
Jan 8, 2015·Seizure : the Journal of the British Epilepsy Association·Eunice S M Yuen, Iñaki F Trocóniz
Apr 27, 2016·Pharmacological Reports : PR·Magdalena Chrościńska-KrawczykStanisław J Czuczwar
Jun 12, 2013·Epilepsy & Behavior : E&B·Christian SamsonsenEylert Brodtkorb
Feb 9, 2018·Neurotoxicity Research·Stefanie EndesfelderChristoph Bührer
Jun 24, 2017·Neurotoxicity Research·Stefanie EndesfelderChristoph Bührer
Mar 29, 2011·Pharmacological Reports : PR·Magdalena Chrościńska-KrawczykStanisław J Czuczwar
May 16, 2019·Current Neurology and Neuroscience Reports·Prisca R Bauer, Josemir W Sander

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