Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid

Neuropharmacology
Jaroslava FolbergrováJakub Otáhal

Abstract

The present study has examined the anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine ((S)-3,4-DCPG), a highly selective agonist for subtype 8 of group III metabotropic glutamate receptors (mGluRs), against seizures induced in immature 12-day-old rats by bilateral icv infusion of DL-homocysteic acid (DL-HCA, 600 nmol/side). For biochemical analyses, rat pups were sacrificed during generalized clonic-tonic seizures, approximately 45-50 min after infusion. Comparable time intervals were used for sacrificing the animals which had received (S)-3,4-DCPG (0.25 nmol/each side, 15-20 min prior to infusion of DL-HCA or saline). This agonist provided a pronounced anticonvulsant effect, generalized clonic-tonic seizures were completely suppressed and cortical energy metabolite changes which normally accompany these seizures were either normalized (decrease of glucose and glycogen) or markedly reduced (an accumulation of lactate). Anticonvulsant effect of (S)-3,4-DCPG was also evident from the EEG recordings, nevertheless, it was not complete. In spite of the absence of obvious motor phenomena, sporadic ictal activity could be seen in some animals. Isolated spikes could also be observed in some animals after admini...Continue Reading

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Citations

Aug 26, 2014·Neurochemical Research·Marion S Mercier, David Lodge
Mar 14, 2014·Amino Acids·Enza PalazzoSabatino Maione
Dec 15, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jaroslava FolbergrováJosef Houštěk
May 5, 2012·Biochemical Pharmacology·Peter J Flor, Francine C Acher
Nov 24, 2011·Experimental Neurology·Jaroslava FolbergrováRastislav Druga
May 3, 2011·Mitochondrion·Jaroslava Folbergrová, Wolfram S Kunz
Jun 16, 2016·Frontiers in Cellular Neuroscience·Jaroslava FolbergrováJakub Otáhal
Nov 17, 2017·International Journal of Molecular Sciences·Paolo BazzigaluppiPeter L Carlen
Feb 26, 2019·Expert Opinion on Therapeutic Targets·Roberta CelliFerdinando Nicoletti
Jun 19, 2019·Current Neuropharmacology·Serena BoccellaEnza Palazzo
Dec 4, 2016·Pharmacological Reports : PR·María CavasJosé Francisco Navarro
Dec 18, 2013·Physiological Research·J Folbergrová

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