PMID: 11900867Mar 20, 2002Paper

Anticonvulsant and neurotoxicity evaluation of some 6-chlorobenzothiazolyl-2-thiosemicarbazones

European Journal of Medicinal Chemistry
Perumal YogeeswariJames Stables

Abstract

Ten 6-chlorobenzothiazolyl-2-thiosemicarbazones were synthesised and screened for anticonvulsant and neurotoxic properties. Most of the compounds showed anticonvulsant activity against both maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole screens. Eight compounds have shown good protection in the rat p.o. MES test at 30 mg kg(-1). Compound 1 [4-(6-chlorobenzothiazol-2-yl)-1-(3-isatinimino)thiosemicarbazone] emerged as the most promising one with an ED(50) of 17.86 and 6.07 mg kg(-1) in mice i.p. and rat p.o., respectively. Compound 1 showed a weak ability to block the expression of fully kindled seizures.

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Citations

Nov 1, 2003·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·P YogeeswariJ P Stables
Sep 9, 2010·Chemical & Pharmaceutical Bulletin·Fatma Abdel-Fattah RagabAhmed Mahmoud El Kerdawy
Jul 28, 2004·European Journal of Medicinal Chemistry·Perumal YogeeswariDharmarajan Sriram
Aug 5, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tomasz PlechGabriel Nowak
Jul 6, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·T A YousefE R El-Rakhawy
Sep 3, 2019·Archiv der Pharmazie·Merve ErtasŞeref Demirayak
Mar 18, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Anand K HalveKiran Tiwari
Sep 28, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rati Kailash Prasad Tripathi, Senthil Raja Ayyannan
Dec 29, 2012·The Journal of Organic Chemistry·Dhananjay KumarVinod K Tiwari

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