journal cover

Anticonvulsant and proconvulsant actions of 2-deoxy-D-glucose

Epilepsia

Aug 1, 2010

Maciej GasiorMichael A. Rogawski

Get paper from

Abstract

2-Deoxy-D-glucose (2-DG), a glucose analog that accumulates in cells and interferes with carbohydrate metabolism by inhibiting glycolytic enzymes, has anticonvulsant actions. Recognizing that severe glucose deprivation can induce seizures, we sought to determine whether acute treatment ...read more

Mentioned in this Paper

Enzymes, antithrombotic
Enzymes, peripheral vasodilators
Kindling, Neurologic
Pentylenetetrazole
Kainate
Dose-Response Relationship, Drug
Enzymes, hematological
Glycolysis Inhibition
3-Hydroxybutyric Acid
Glucose Metabolism
1
28
Paper Details
References
  • References46
  • Citations23
123

Anticonvulsant and proconvulsant actions of 2-deoxy-D-glucose

Epilepsia

Aug 1, 2010

Maciej GasiorMichael A. Rogawski

PMID: 20491877

DOI: 10.1111/j.1528-1167.2010.02593.x

Abstract

2-Deoxy-D-glucose (2-DG), a glucose analog that accumulates in cells and interferes with carbohydrate metabolism by inhibiting glycolytic enzymes, has anticonvulsant actions. Recognizing that severe glucose deprivation can induce seizures, we sought to determine whether acute treatment ...read more

Mentioned in this Paper

Enzymes, antithrombotic
Enzymes, peripheral vasodilators
Kindling, Neurologic
Pentylenetetrazole
Kainate
1
28

Related Papers

Paper Details
References
  • References46
  • Citations23
123

Get paper from

/papers/anticonvulsant-and-proconvulsant-actions-of-2-deox/20491877