PMID: 3319542Jan 1, 1987Paper

Anticonvulsant drugs and cognitive function: a review of the literature

Epilepsia
M R Trimble

Abstract

Alterations of cognitive function are separate from disturbances of behavior seen in association with epilepsy. The nature of the cognitive disability may to a certain extent depend on the seizure type. Partial seizures, mainly derived from a temporal lobe focus, impair memory tasks, while generalized seizures seem to have more effect on attentional abilities. A number of studies, reviewed in this paper, suggest that anticonvulsant drugs further impair cognitive function. Maximal impairments are seen in patients receiving polytherapy: rationalization of polytherapy improves cognitive abilities. Studies in children and adults have allowed differentiation of the effects of various commonly used antiepileptic agents. Maximal cognitive deficits are seen with phenytoin, while phenobarbital and sodium valproate induce moderate disturbances, and carbamazepine seems relatively free from such toxicity. Further research is needed on the interrelationship between types of seizure disorders, types of anticonvulsant medications, and cognitive function.

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References

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Citations

Mar 1, 1994·Journal of Clinical Psychology in Medical Settings·J J SweetN A Vick
Jan 1, 1993·European Journal of Clinical Pharmacology·H V Curran, R Java
Jun 14, 2008·Psychopharmacology·Kristiina KaskInger Sundström-Poromaa
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Jul 27, 1999·Pharmacology, Biochemistry, and Behavior·M K BanksP E Garraghty
Sep 9, 1989·Lancet
May 24, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·M K BanksP E Garraghty
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Nov 10, 1998·Seizure : the Journal of the British Epilepsy Association·C MortimoreE Emmers
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Mar 1, 2003·Epilepsy & Behavior : E&B·Nadine H.J. EngelbertsDorotheé G.A. Kasteleijn-Nolst Trenité
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Jun 26, 2003·Epilepsia·Albert P AldenkampRianne Reijs
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Dec 3, 2014·Epilepsy & Behavior : E&B·Christoph Helmstaedter, Juri-Alexander Witt
Dec 1, 1993·Neuropsychologia·I JambaquéJ L Signoret

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