Anticonvulsant effects of diazepam and MK-801 in soman poisoning
Epilepsy Research
Nov 1, 1990
T M Shih
PMID: 2289469
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Abstract
An animal model was developed to evaluate the anticonvulsant effects of diazepam and MK-801 in soman poisoning and to examine the possible mechanism of soman-induced convulsions. The oxime HI-6 (125 mg/kg, i.p.) was given to male rats, to increase survival, 30 min prior to 180 microgram...read more
Mentioned in this Paper
Anticholinergic [EPC]
Atropine Sulfate Anhydrous
Antidote
Diazepam
MK-801
Dose-Response Relationship, Drug
Metazoa
Pyridinium Compounds
Dizocilpine
Anticholinergic Agents
Paper Details
References
- References31
- Citations48
Polysomnography and hypnotics
The Annals of Physiological Anthropology = Seiri Jinruigaku Kenkyūkai KaishiOctober 1, 1985T Kotorii
Seizure-related brain damage induced by cholinergic agents
NatureFebruary 10, 1983John W OlneyJoann Labruyere
Modification of cholinergically induced convulsive activity and cyclic GMP levels in the CNS
NeuropharmacologyJanuary 1, 1983Paul M Lundy, Rob K Shaw
Ganglion blocking properties of some bispyridinium soman antagonists
European Journal of PharmacologyNovember 23, 1979Paul M Lundy, Ken Tremblay
Examination of the role of central cholinergic mechanisms in the therapeutic effects of HI-6 in organophosphate poisoning
Journal of NeurochemistryMay 1, 1983Paul M Lundy, T M Shih
Effect of diazepam upon soman-induced seizure activity and convulsions
Electroencephalography and Clinical NeurophysiologyMay 1, 1972J A LippPharmacological actions of HS-6, an oxime, on the neuromuscular junction
European Journal of PharmacologyJanuary 1, 1979John Gerald Clement12
New concepts on the mechanism of action of benzodiazepines
Life SciencesJuly 15, 1975Ernane José Xavier CostaA SuriaEffects of diazepam on epileptiform patterns of bioelectrical activity of the rabbit's brain induced by fluostigmine
NeuropharmacologyAugust 1, 1973Sławomir RumpZ Edelwejn
Delayed recovery from a sedative: correlation of the plasma levels of diazepam with clinical effects after oral and intravenous administration
British Journal of AnaesthesiaAugust 1, 1972E S Baird, D M Hailey
1234
- References31
- Citations48
Pharmacological modulation of soman-induced seizures
Neuroscience and Biobehavioral ReviewsJanuary 1, 1993John H McDonough, T M Shih
NMDA antagonists exert distinct effects in experimental organophosphate or carbamate poisoning in mice
Toxicology and Applied PharmacologyMarch 1, 2007Andrzej DekundyWaldemar Andrzej Turski
Treatment of status epilepticus with ketamine, are we there yet?
CNS Neuroscience & TherapeuticsJune 1, 2013Fréderic DorandeuGuy Testylier867
Organophosphorus nerve agents-induced seizures and efficacy of atropine sulfate as anticonvulsant treatment
Pharmacology, Biochemistry, and BehaviorSeptember 1, 1999T M Shih, John H McDonough
Effects of selected anticholinergics on acoustic startle response in rats
Journal of Applied Toxicology : JATDecember 1, 2001Maurice L SiposGregory Galbicka
Anticonvulsants for soman-induced seizure activity
Journal of Biomedical ScienceMarch 24, 1999T M ShihIrwin Koplovitz5
Multifunctional drugs as novel antidotes for organophosphates' poisoning
ToxicologyDecember 18, 2011Ben Avi Weissman, Lily Raveh
Acute toxicity of some nerve agents and pesticides in rats
Drug and Chemical ToxicologyJanuary 1, 2015Jan MisikKamil Kuca1420Dose-response effects of atropine and HI-6 treatment of organophosphorus poisoning in guinea pigs
Drug and Chemical ToxicologyJanuary 1, 1995Irwin KoplovitzShalonda Kelly
Bioavailability of diazepam after intramuscular injection of its water-soluble prodrug alone or with atropine-pralidoxime in healthy volunteers
British Journal of PharmacologyAugust 1, 2009Chadi AbbaraBertrand Diquet14
12345
Related Papers
Pharmacological modulation of soman-induced seizures
Neuroscience and Biobehavioral ReviewsJanuary 1, 1993
John H McDonough, T M Shih
NMDA antagonists exert distinct effects in experimental organophosphate or carbamate poisoning in mice
Toxicology and Applied PharmacologyMarch 1, 2007
Andrzej DekundyWaldemar Andrzej Turski
Anticonvulsant effects of diazepam and MK-801 in soman poisoning
Abstract
An animal model was developed to evaluate the anticonvulsant effects of diazepam and MK-801 in soman poisoning and to examine the possible mechanism of soman-induced convulsions. The oxime HI-6 (125 mg/kg, i.p.) was given to male rats, to increase survival, 30 min prior to 180 microgram...read more
Mentioned in this Paper
Anticholinergic [EPC]
Atropine Sulfate Anhydrous
Antidote
Diazepam
MK-801
Related Papers
Paper Details
References
- References31
- Citations48
Polysomnography and hypnotics
The Annals of Physiological Anthropology = Seiri Jinruigaku Kenkyūkai KaishiOctober 1, 1985T KotoriiSeizure-related brain damage induced by cholinergic agents
NatureFebruary 10, 1983John W OlneyJoann LabruyereModification of cholinergically induced convulsive activity and cyclic GMP levels in the CNS
NeuropharmacologyJanuary 1, 1983Paul M Lundy, Rob K ShawGanglion blocking properties of some bispyridinium soman antagonists
European Journal of PharmacologyNovember 23, 1979Paul M Lundy, Ken TremblayExamination of the role of central cholinergic mechanisms in the therapeutic effects of HI-6 in organophosphate poisoning
Journal of NeurochemistryMay 1, 1983Paul M Lundy, T M ShihEffect of diazepam upon soman-induced seizure activity and convulsions
Electroencephalography and Clinical NeurophysiologyMay 1, 1972J A LippPharmacological actions of HS-6, an oxime, on the neuromuscular junction
European Journal of PharmacologyJanuary 1, 1979John Gerald Clement12New concepts on the mechanism of action of benzodiazepines
Life SciencesJuly 15, 1975Ernane José Xavier CostaA SuriaEffects of diazepam on epileptiform patterns of bioelectrical activity of the rabbit's brain induced by fluostigmine
NeuropharmacologyAugust 1, 1973Sławomir RumpZ EdelwejnDelayed recovery from a sedative: correlation of the plasma levels of diazepam with clinical effects after oral and intravenous administration
British Journal of AnaesthesiaAugust 1, 1972E S Baird, D M Hailey
1234
- References31
- Citations48
Pharmacological modulation of soman-induced seizures
Neuroscience and Biobehavioral ReviewsJanuary 1, 1993John H McDonough, T M ShihNMDA antagonists exert distinct effects in experimental organophosphate or carbamate poisoning in mice
Toxicology and Applied PharmacologyMarch 1, 2007Andrzej DekundyWaldemar Andrzej TurskiTreatment of status epilepticus with ketamine, are we there yet?
CNS Neuroscience & TherapeuticsJune 1, 2013Fréderic DorandeuGuy Testylier867Organophosphorus nerve agents-induced seizures and efficacy of atropine sulfate as anticonvulsant treatment
Pharmacology, Biochemistry, and BehaviorSeptember 1, 1999T M Shih, John H McDonoughEffects of selected anticholinergics on acoustic startle response in rats
Journal of Applied Toxicology : JATDecember 1, 2001Maurice L SiposGregory GalbickaAnticonvulsants for soman-induced seizure activity
Journal of Biomedical ScienceMarch 24, 1999T M ShihIrwin Koplovitz5Multifunctional drugs as novel antidotes for organophosphates' poisoning
ToxicologyDecember 18, 2011Ben Avi Weissman, Lily RavehAcute toxicity of some nerve agents and pesticides in rats
Drug and Chemical ToxicologyJanuary 1, 2015Jan MisikKamil Kuca1420Dose-response effects of atropine and HI-6 treatment of organophosphorus poisoning in guinea pigs
Drug and Chemical ToxicologyJanuary 1, 1995Irwin KoplovitzShalonda KellyBioavailability of diazepam after intramuscular injection of its water-soluble prodrug alone or with atropine-pralidoxime in healthy volunteers
British Journal of PharmacologyAugust 1, 2009Chadi AbbaraBertrand Diquet14
12345
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