Anticonvulsant effects of GABA(A) modulators microinfused into area tempestas or substantia nigra in rats exposed to soman

Archives of Toxicology
T MyhrerPål Aas

Abstract

Enhancement of GABAergic neurotransmission has anticonvulsant effects against nerve agent-induced seizures. However, systemic administration of drugs with GABA(A) agonist-like effects does not differentiate well between their anticonvulsant impact. In the present study, GABA(A) modulating drugs (1 microl) were microinfused bilaterally into the seizure controlling substrates, substantia nigra (SN) or area tempestas (AT), of rats subjected to seizures induced systemically by soman (100 microg/kg). The results showed that infusion of ethanol (0.47 micromol) and propofol (20 microg) in both SN and AT icrohad anticonvulsant effects (prevention of seizures or increased latency to seizures). Anticonvulsant effects were also obtained when muscimol (120 ng) was infused into AT or when diazepam (5 microg) was infused into SN. Pentobarbital (50 microg) did not attenuate soman-elicited seizures in any of the injection sites. Results from control experiments showed that the effects from the microinfusions were site-specific, and that the absence of effects of pentobarbital was not a result of too low dose of the drug. The microinfusion technique may allow a more detailed examination of anticonvulsant properties of drugs than by the use of s...Continue Reading

References

Feb 1, 1992·Pharmacology, Biochemistry, and Behavior·S I DeutschJ Mastropaolo
Jun 18, 1990·Brain Research·L TurskiE A Cavalheiro
Oct 1, 1982·The Journal of Pharmacy and Pharmacology·F MoroniA Guidotti
Jan 1, 1984·Drug and Chemical Toxicology·L W HarrisW J Lennox
Nov 14, 1997·Neuroscience and Biobehavioral Reviews·J H McDonough, T M Shih
Jan 29, 2000·Archives of Toxicology·J H McDonoughT M Shih
Aug 9, 2002·European Journal of Pharmacology·Peggy JouvertJean Zwiller

❮ Previous
Next ❯

Citations

Aug 20, 2009·Journal of Molecular Neuroscience : MN·Jacob W SkoviraTsung-Ming Shih
Apr 18, 2008·Canadian Journal of Physiology and Pharmacology·Dusan MladenovićOlivera Stanojlović
Sep 25, 2012·Critical Care Clinics·Matthew W Hedge
Jun 16, 2015·Frontiers in Neural Circuits·Marta S VismerMohamad Z Koubeissi
Jul 10, 2012·Neurotoxicology·Jacob W SkoviraJohn H McDonough
Mar 1, 2012·Annals of Neurology·Robert S Fisher
Feb 10, 2007·Toxicology and Applied Pharmacology·Kristin Huse HaugFrode Fonnum

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.