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Anticonvulsant efficacy of antihistamine cyproheptadine in rats exposed to the chemical warfare nerve agent soman

Neurotoxicology

Jan 1, 2017

Jennifer L WinklerRobert K Kan

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Abstract

Organophosphate compounds, such as soman and sarin, are highly toxic chemical warfare nerve agents that cause a build-up of acetylcholine in synapses and neuromuscular junctions. Current therapies aim to prevent seizures and protect against brain injury following exposure. The present s...read more

Mentioned in this Paper

In Situ Nick-End Labeling
Synapses
Acetylcholine Measurement
Viternum
Cell Death
Study
Evaluation
Dose-Response Relationship, Drug
Methylatropine nitrate
Metazoa
Paper Details
References
  • References25
  • Citations1
123

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Anticonvulsant efficacy of antihistamine cyproheptadine in rats exposed to the chemical warfare nerve agent soman

Neurotoxicology

Jan 1, 2017

Jennifer L WinklerRobert K Kan

PMID: 27988303

DOI: 10.1016/j.neuro.2016.12.004

Abstract

Organophosphate compounds, such as soman and sarin, are highly toxic chemical warfare nerve agents that cause a build-up of acetylcholine in synapses and neuromuscular junctions. Current therapies aim to prevent seizures and protect against brain injury following exposure. The present s...read more

Mentioned in this Paper

In Situ Nick-End Labeling
Synapses
Acetylcholine Measurement
Viternum
Cell Death

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References25
  • Citations1
123

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