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Anticonvulsant evaluation and docking analysis of VV-Hemorphin-5 analogues

Drug Development Research

Jan 27, 2019

Petar TodorovJana Tchekalarova

Abstract

VV-Hemorphin-5 is an endogenous opioid peptide of the Hemorphin family with affinity at opioid receptors. A series of C-amide analogues have been synthesized, based on the structure of VV-Hemorphin-5, modified at position 1 and 7 by the un/natural amino acids (Aa8-Val-Val-Tyr-Pro-Trp-Th...read more

Mentioned in this Paper

Chemical Procedure
VV-hemorphin-5
Opioid Peptide
Spinorphin
Evaluation
Laboratory Procedures
Analogs & derivatives
Neurotoxicity Syndromes
Motor Coordination
Preclinical Study
Paper Details
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Anticonvulsant evaluation and docking analysis of VV-Hemorphin-5 analogues

Drug Development Research

Jan 27, 2019

Petar TodorovJana Tchekalarova

PMID: 30681179

DOI: 10.1002/ddr.21514

Abstract

VV-Hemorphin-5 is an endogenous opioid peptide of the Hemorphin family with affinity at opioid receptors. A series of C-amide analogues have been synthesized, based on the structure of VV-Hemorphin-5, modified at position 1 and 7 by the un/natural amino acids (Aa8-Val-Val-Tyr-Pro-Trp-Th...read more

Mentioned in this Paper

Chemical Procedure
VV-hemorphin-5
Opioid Peptide
Spinorphin
Evaluation
Laboratory Procedures
Analogs & derivatives
Neurotoxicity Syndromes
Motor Coordination
Preclinical Study

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