Anticonvulsant properties of gamma-decanolactone in mice

Journal of Ethnopharmacology
G P Coelho de SouzaM Nascimento da Silva

Abstract

Lactones have been proven to be bioactive. We have shown that compounds present in the essential oil from Aeollanthus suaveolens, used as an anticonvulsant in the Brazilian Amazon, has sedative properties. This paper reports on the evaluation of the systemic administration of gamma-decanolactone, structurally related to lactones present in the essential oil of A. suaveolens, on mice experimental models useful for detecting psychopharmacological activity. The results show that gamma-decanolactone has dose-dependent marked effects on the central nervous system, including hypnotic, anticonvulsant and hypothermic activity. The effects of gamma-decanolactone revealed by this evaluation point to the validity of exploring lactones as sources of new anticonvulsant agents.

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Citations

Nov 9, 2002·International Journal of Food Microbiology·Mario AguedoJean-Marc Belin
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Feb 6, 2008·Experimental Brain Research·Paulo Alexandre de OliveiraPatrícia Pereira
Jul 28, 2009·Phytochemistry·Patricia RijoBenjamín Rodríguez
Jan 9, 2007·Life Sciences·Carla Cristina Soares VianaPatrícia Pereira
Mar 29, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Reinaldo Nóbrega de AlmeidaDamião Pergentino de Sousa
Sep 20, 2018·Fundamental & Clinical Pharmacology·Cícero Francisco Bezerra FelipeReinaldo Nóbrega de Almeida
Nov 7, 2006·Veterinary Dermatology·David McEwan JenkinsonDouglas L Bovell
Jul 24, 2020·Behavioural Pharmacology·Pricila PflügerPatrícia Pereira
Sep 3, 2020·Drug Delivery and Translational Research·Thamara de Oliveira FerrazCaio Pinho Fernandes
Jun 27, 2021·European Journal of Pharmacology·Pricila PflügerJosé A Fontenla
Oct 31, 2002·Journal of Agricultural and Food Chemistry·Sheikh Julfikar HossainYoshinobu Kiso

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