PMID: 7373552Apr 1, 1980Paper

Anticonvulsant properties of selected pyrrolo[2,3-d]pyrimidine-2,4-diones and intermediates

Journal of Pharmaceutical Sciences
D L PowersJ W Kosh

Abstract

A series of pyrrolo[2,3-d]pyrimidine-2,4-diones and intermediates was tested for anticonvulsant activity in mice. Eleven of the 15 compounds possessed anticonvulsant activity against pentylenetetrazol-induced convulsions. One compound afforded more anticonvulsant protection against pentylenetetrazol than did trimethadione (67 and 50%, respectively). A suspension of this compound was found to be as effective as a solution in producing anticonvulsant activity. The results suggest that the nitrile analogs were more potent compared to the carbamyl analog due to higher lipid solubility.

References

Oct 30, 1970·Annals of the New York Academy of Sciences·J S Remington, L O Gentry

Related Concepts

Anticonvulsants
Electroconvulsive Shock
Pentazol
Hydantol
Pyrimidones
Pyrroles
Non-epileptic Convulsion
Structure-Activity Relationship
Trimetin

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