PMID: 6401628Feb 1, 1983Paper

Anticonvulsant sensitivity of absence seizures in the tottering mutant mouse

Epilepsia
A H HellerR L Sidman

Abstract

Homozygous tottering mice (tg, autosomal recessive) exhibit frequent spontaneous "absence" seizures accompanied by bilaterally synchronous spike-and-wave or polyspike electrocorticographic discharges. In adult tottering mice, the antiepileptic effects of a single dose of ethosuximide, diazepam, phenobarbital, or phenytoin were assessed using continuous electrocorticographic recording to monitor seizure incidence. The dose chosen for each drug was selected to correspond to an effective antiepileptic dose in standard murine models. Ethosuximide, 150 mg/kg, diazepam, 1.4 mg/kg, and phenobarbital, 25 mg/kg were effective against absence seizures. In contrast, phenytoin at 5, 10, 30, or 60 mg/kg produced no significant reduction in the incidence of absence seizures. These results suggest that absence seizures in the tottering mutant may represent a relatively specific pharmacological model for the identification of drugs effective for clinical absence epilepsy, and emphasize the potential value of this new model for the study of fundamental mechanisms of absence of epilepsy and the actions of antiepileptic drugs.

Citations

Jun 19, 1992·Pharmaceutisch Weekblad. Scientific Edition·H J Kupferberg
Feb 1, 1995·Italian Journal of Neurological Sciences·J L Noebels
Nov 26, 1985·European Journal of Pharmacology·S M TaylorR H Finnell
Oct 1, 1990·Brain Research Bulletin·L C AbbottA S Hassan
Jul 1, 1992·Epilepsy Research·A M CoenenE L van Luijtelaar
Aug 2, 2002·Pharmacology, Biochemistry, and Behavior·Brandy E FuremanEllen J Hess
Oct 22, 2003·Progress in Neurobiology·Justyna R Sarna, Richard Hawkes
Oct 10, 2002·Brain Research Bulletin·M CicaleA de Bartolomeis
Sep 9, 1999·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·D A Hosford
Mar 1, 1985·Epilepsia·T N Seyfried, G H Glaser
Mar 24, 1998·Annual Review of Medicine·C W Bazil, T A Pedley
Dec 17, 2008·The Cerebellum·Freek E HoebeekChris I De Zeeuw
Jan 20, 2009·Neurobiology of Disease·Wendy K ChungDane M Chetkovich
Sep 24, 2004·Epilepsy & Behavior : E&B·Inna S MidzyanovskayaGilles van Luijtelaar
May 24, 2015·Biochemical and Biophysical Research Communications·Tae Yeon KimEiki Takahashi
Jan 1, 1993·Epilepsia·J R Buchhalter

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