Anticonvulsant therapy in small animals

The Veterinary Clinics of North America. Small Animal Practice
D M Boothe

Abstract

Successful control of seizures with anticonvulsant drugs reflects a balance in achieving seizure control while minimizing undesirable drug side effects. Variability in the disposition of anticonvulsants and interaction among them are important confounders of successful therapy. This article will provide a review of selected anticonvulsants, focusing on drugs most likely to control seizures in small animals. The proper use of anticonvulsants will be discussed, with emphasis on differences in individual drug disposition, detection of these differences, and rational approaches to responding to these differences by dose modification. The primary target of discussion will be treatment of generalized, tonic clonic seizures, the most common type afflicting small animals. Opinions regarding anticonvulsive therapy vary among clinicians. Most of the comments and recommendations offered in this discussion reflect observations made from our therapeutic drug monitoring service and completed and ongoing clinical trials that focus on the use of anticonvulsants used either alone or in combination with phenobarbital.

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Citations

Dec 29, 2000·Journal of Veterinary Pharmacology and Therapeutics·C L GaskillA E Cribb
Apr 25, 2009·Journal of Feline Medicine and Surgery·Kerry Smith Bailey, Curtis W Dewey
Mar 4, 2014·The Veterinary Clinics of North America. Small Animal Practice·James A Lavely
Jul 31, 2013·The Veterinary Clinics of North America. Small Animal Practice·Karen R Muñana
Nov 28, 2009·The Veterinary Clinics of North America. Small Animal Practice·William B Thomas
Dec 1, 2004·Veterinary Clinical Pathology·Cynthia L GaskillAlastair E Cribb
Nov 13, 2008·Journal of Veterinary Pharmacology and Therapeutics·K FukunagaK Orito
Jan 12, 2011·Journal of Veterinary Pharmacology and Therapeutics·S E MusulinM G Papich
Feb 19, 2000·The Veterinary Clinics of North America. Small Animal Practice·W B Thomas
May 30, 2012·New Zealand Veterinary Journal·J Y ChungH Y Youn
Apr 27, 2017·Journal of Veterinary Emergency and Critical Care·Susan Blades Golubovic, John H Rossmeisl
Aug 24, 2005·Nature Medicine·Guo-Feng TianMaiken Nedergaard
Jun 8, 2001·Journal of the American Veterinary Medical Association·D L ZoranD M Boothe
Mar 18, 2008·Journal of the American Veterinary Medical Association·Kerry Smith BaileyGregg D Kortz
Oct 22, 2002·Journal of the American Veterinary Medical Association·Dawn Merton BoothePauline Couch
Mar 29, 2012·American Journal of Veterinary Research·Joseph S EaglesonCatherine A White
Jul 9, 2004·Journal of the American Animal Hospital Association·Curtis W DeweySteven C Budsberg
Jun 3, 2020·Journal of Feline Medicine and Surgery·Oliver MarshLuisa De Risio
Dec 22, 1999·The Veterinary Record·G Steenkamp, D A Crossley
Mar 3, 2012·Journal of the American Veterinary Medical Association·Hope E Baird-HeinzLaura L Hungerford
Mar 11, 2020·Frontiers in Veterinary Science·Liana M YatesMunashe Chigerwe

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