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Anticonvulsant treatment of nerve agent seizures: anticholinergics versus diazepam in soman-intoxicated guinea pigs

Epilepsy Research

Jan 1, 2000

John H McDonoughT M Shih

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Abstract

A total of eight anticholinergic drugs (aprophen, atropine, azaprophen, benactyzine, biperiden, procyclidine, scopolamine, trihexyphenidyl) were tested in parallel with diazepam for the ability to terminate seizure activity induced by the nerve agent soman. Guinea pigs, implanted with e...read more

Mentioned in this Paper

Anticholinergic [EPC]
Acetylcholine Measurement
Antidote
Azaprophen
Diazepam
Pseudocholinesterase
Nervous System Structure
Tremor
Weighing Patient
Procyclidine hydrochloride
Paper Details
References
  • References30
  • Citations46
12345

Anticonvulsant treatment of nerve agent seizures: anticholinergics versus diazepam in soman-intoxicated guinea pigs

Epilepsy Research

Jan 1, 2000

John H McDonoughT M Shih

PMID: 10604601

DOI: 10.1016/s0920-1211(99)00060-1

Abstract

A total of eight anticholinergic drugs (aprophen, atropine, azaprophen, benactyzine, biperiden, procyclidine, scopolamine, trihexyphenidyl) were tested in parallel with diazepam for the ability to terminate seizure activity induced by the nerve agent soman. Guinea pigs, implanted with e...read more

Mentioned in this Paper

Anticholinergic [EPC]
Acetylcholine Measurement
Antidote
Azaprophen
Diazepam

Related Papers

Paper Details
References
  • References30
  • Citations46
12345

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