Anticonvulsants for cocaine dependence

The Cochrane Database of Systematic Reviews
S MinozziS Vecchi

Abstract

Cocaine dependence is a major public health problem that is characterized by recidivism and a host of medical and psychosocial complications. Although effective pharmacotherapy is available for alcohol and heroin dependence none exists currently for cocaine dependence despite two decades of clinical trials primarily involving antidepressant, anti convulsivant and dopaminergic medications. There has been extensive consideration of optimal pharmacological approaches to the treatment of cocaine dependence with consideration of both dopamine antagonists and agonists. Anticonvulsants have been candidates for the treatment of addiction based on the hypothesis that seizure kindling-like mechanisms contribute to addiction. To evaluate the efficacy and the acceptability of anticonvulsants for cocaine dependence We searched the Cochrane Drugs and Alcohol Groups specialised register (issue 4, 2007), MEDLINE (1966 - march 2007), EMBASE (1988 - march 2007), CINAHL (1982- to march 2007) All randomised controlled trials and controlled clinical trials which focus on the use of anticonvulsants medication for cocaine dependence Two authors independently evaluated the papers, extracted data, rated methodological quality Fifteen studies (1066 part...Continue Reading

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