Anticonvulsive properties of F1933 (dulozafone) on kindled seizures in the rat

European Journal of Pharmacology
M Lerner-NatoliM Briley

Abstract

The anticonvulsive properties of a new compound: F1933 (Dulozafone) were investigated in the amygdala kindling model and compared with those of diazepam. Both drugs protected fully kindled rats against generalized seizures but failed to suppress partial ictal events (amygdala afterdischarges and limbic seizures). The anticonvulsive action of F1933, administered at the ED100, was nearly reversed by the specific antagonist of benzodiazepines receptors; R015-1788 (Flumazenil), suggesting that the effect of F1933 is mediated by this receptor. These results also emphasize the usefulness of kindling to test antiepileptic drugs and to confirm their supposed profile of action.

References

Jul 1, 1986·Experimental Neurology·W LöscherS J Czuczwar
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Jul 1, 1973·Pharmacology, Biochemistry, and Behavior·R G Babington, P W Wedeking
Nov 1, 1969·Experimental Neurology·G V GoddardC K Leech
Jan 1, 1982·Folia Psychiatrica Et Neurologica Japonica·Y MoritaK Miyoshi
Feb 1, 1981·Electroencephalography and Clinical Neurophysiology·S L PetersonL S Gordon
Jan 21, 1983·European Journal of Pharmacology·J O McNamaraM T Galloway
Jul 1, 1980·Neuropharmacology·T E AlbertsonL G Stark

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