Anticytokine Activity Enhances Osteogenesis of Bioactive Implants.

Tissue Engineering. Part a
Fan YangErnst B Hunziker

Abstract

In dental clinical practice, systemic steroids are often applied at the end of implant surgeries to reduce postsurgical inflammation (tissue swelling, etc.) and to reduce patient discomfort. However, the use of systemic steroids is associated with generalized catabolic effects and with a temporarily reduced immunological competence. We hypothesize that by applying locally anticytokine antibodies (antitumor necrosis factor alpha and anti-interleukin-1 beta) together with a bioactive osteogenic implant at the time of the surgical intervention for the placement of a construct, we will be able to achieve the same beneficial effects as those using systemic steroids but are able to avoid the generalized antianabolic effects and the reduced immunocompetence effects, associated with the systemic use of steroids. In an adult rat model, a collagen sponge, soaked with the osteogenic agent bone morphogenetic protein-2, was used as an example for a bioactive implant material and was surgically placed subcutaneously. In the acute inflammatory phase after implantation (2 days after surgery) we investigated the local inflammatory tissue response, and 18 days postsurgically the efficiency of local osteogenesis (to assess possible antianabolic e...Continue Reading

References

Mar 11, 1989·British Dental Journal·R L Caplin
May 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H J GundersenA Vesterby
Sep 1, 1987·Journal of Microscopy·H J Gundersen, E B Jensen
Nov 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Daniel S PerrienCharles K Lumpkin
Dec 25, 2007·Pharmacology & Therapeutics·Daniel TraceyPaul P Tak
Mar 28, 2008·Autoimmunity·Georg Schett
May 7, 2008·Biomedical Materials·Zhidao Xia, James T Triffitt
Jun 6, 2009·The Journal of the American Dental Association·Joel J NapeñasPeter B Lockhart
Jan 29, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Fu-Hsiumg LinBrian E Brigman
Nov 24, 2011·Clinical Therapeutics·Mary Barna Bridgeman, Rolee Pathak
Jun 8, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kwang-Bok LeeJeffrey C Wang
Jan 29, 2013·International Journal of Oncology·Eijiro JimiJingo Kusukawa
Jun 14, 2013·Clinical & Developmental Immunology·Hideki KitauraTeruko Takano-Yamamoto
Jan 30, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ozgur IlhanNedim Gunes
Dec 10, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Linda ViBenjamin A Alman
Apr 29, 2015·The Journal of Clinical Endocrinology and Metabolism·Lindsay M GriffinMary B Leonard
Sep 8, 2015·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Gino InversoLeonard B Kaban
Oct 27, 2015·Clinical Reviews in Allergy & Immunology·Nicole J Horwood
Nov 5, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Benjamin P SinderLaurie K McCauley
Nov 18, 2015·Clinical Reviews in Allergy & Immunology·Mary Beth Humphrey, Mary C Nakamura
Mar 2, 2017·International Journal of Molecular Sciences·Hairong HuangGang Wu
Mar 2, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Laura Y LuStuart B Goodman
May 26, 2017·Journal of Cellular Physiology·Yixuan CaoVincent Everts
Oct 25, 2017·European Journal of Plastic Surgery·Mohamed IbrahimHoward Levinson
Dec 11, 2017·Acta Biomaterialia·Michael B Christensen, Patrick A Tresco
Dec 14, 2017·Scandinavian Journal of Gastroenterology·Shahrad HakimianBenjamin Hyatt
Jan 13, 2018·The Journal of Clinical Endocrinology and Metabolism·Mark D DeBoerMary B Leonard
Apr 17, 2018·European Journal of Dentistry·Daniel Amaral Alves MarlièreHenrique Duque De Miranda Chaves Netto
Sep 12, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Jiezhong DengZehua Zhang

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