Anticytokine therapies in systemic lupus erythematosus.

Immunotherapy
Antonio La Cava

Abstract

The dysfunctional immune response that characterizes systemic lupus erythematosus (SLE) associates with an unbalanced production of soluble mediators that are crucial in promoting and sustaining chronic inflammation. The successful use of biologics in several autoimmune diseases has led to studies in SLE aimed at contrasting the proinflammatory responses that contribute to tissue and organ damage in the disease. Several approaches have been developed and tested as potential therapeutic agents in SLE in preclinical studies and in clinical trials. This article provides an overview on antibody-based approaches in SLE that, although preliminary, have the potential to expand the current therapeutic possibilities in the disease.

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Jun 19, 2013·Human Immunology·Nadja Maria AsanoPaulo Eleutério Souza
Oct 27, 2011·Journal of Biomedicine & Biotechnology·Kim Ohl, Klaus Tenbrock
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Jun 15, 2021·International Immunopharmacology·Shabnam RadbakhshAmirhossein Sahebkar

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Clinical Trials Mentioned

NCT00657007
NCT00071487
NCT00424476
NCT00583362
NCT00724867
NCT00712933
NCT00410384
NCT00732940
NCT00573157
NCT00624338

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