Antidepressant, anxiogenic, and antinociceptive properties of levofloxacin in rats and mice

Pharmacology, Biochemistry, and Behavior
B F ErdenN Gacar

Abstract

Levofloxacin, an optically active isomer of ofloxacin, is a fluorinated quinolone with a broad spectrum of antibacterial activity. Fluoroquinolones have been used for the treatment of bacterial infections for many years. Although they were considered as relatively safe drugs, various adverse effects have recently been reported along with increase in the usage of new-generation fluoroquinolones. In the present study, some of the central nervous system (CNS)-related side effects of levofloxacin were clarified in animals. Our results suggested that: levofloxacin (10-20-40 mg/kg i.p.) had no depression-like effect in the forced swimming test (FST) in rats; exerted anxiety-like effect in the elevated plus maze test in rats; did not alter the locomotor activity in rats; had no apparent effect on sleep latency but shortened the sleeping time on pentobarbital sleeping time in mice; and showed analgesic activity in acetic acid writhing and hot plate test in mice.

References

Feb 15, 1978·European Journal of Pharmacology·R D PorsoltM Jalfre
Sep 1, 1991·Pharmacology, Biochemistry, and Behavior·N EnginarG Ulak
Sep 1, 1988·Antimicrobial Agents and Chemotherapy·T UneY Osada
Jan 1, 1981·Progress in Neuro-psychopharmacology·J A GrayS R Owen
Aug 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·S L Handley, S Mithani
Nov 1, 1994·The Journal of Antimicrobial Chemotherapy·Y TsutomiK Akahane
Jun 17, 1995·Lancet·A J Norheim, V Fønnebø
May 1, 1996·Diagnostic Microbiology and Infectious Disease·G M EliopoulosR C Moellering
Feb 1, 1997·Clinical Pharmacokinetics·D N Fish, A T Chow
Jan 1, 1997·Biology of the Neonate·G YildiranF Erden
Aug 24, 1999·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·H Lode

❮ Previous
Next ❯

Citations

May 21, 2011·Journal of Molecular Neuroscience : MN·Elimelech NesherAlbert Pinhasov
Jan 1, 2008·Indian Journal of Psychiatry·Nagaraja MoorthyP N Venkatarathnamma
Feb 22, 2012·Journal of Neurosciences in Rural Practice·Somsri Wiwanitkit, Viroj Wiwanitkit
Nov 21, 2007·European Journal of Pharmacology·Nidhi BharalKrishna Kishore Sharma
Feb 13, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Tingli LiChunyu Sun
Feb 15, 2005·Clinical Neurology and Neurosurgery·Elif HakkoAli Mert
May 3, 2014·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Yuefeng LiAnguo Liu
Nov 13, 2014·Journal of Basic and Clinical Physiology and Pharmacology·Rohita ShettyYeshwant Deshmukh
May 9, 2021·Research in Veterinary Science·Andrejs SitovsMario Giorgi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pharmacology, Biochemistry, and Behavior
N EnginarG Ulak
Journal of Neurosciences in Rural Practice
Rajniti PrasadOp Mishra
Progress in Neuro-psychopharmacology & Biological Psychiatry
B HesslingerM Berger
© 2021 Meta ULC. All rights reserved