Antidepressant, anxiolytic and procognitive effects of rivastigmine and donepezil in the chronic mild stress model in rats

Psychopharmacology
M PappP Willner

Abstract

The treatment of depression in old age is complicated by frequent co-morbidity with cognitive impairment. Anti-dementia drugs have some efficacy to improve cognitive performance and there is an inconsistent literature regarding the effect of such drugs on depressive symptoms. Here, we have investigated whether anti-dementia drugs would have antidepressant-like and pro-cognitive effects in a well-validated animal model of depression and cognitive impairment, chronic mild stress (CMS). Rats were subjected to CMS for a total of 8 weeks. After 2 weeks, subgroups of stressed and non-stressed animals were treated daily, for 5 weeks followed by 1 week of drug withdrawal, with vehicle, imipramine (10 mg/kg), rivastigmine (2 mg/kg), donepezil (0.3 mg/kg) or memantine (5 mg/kg). Sucrose intake was tested weekly, and animals were also tested in the elevated plus maze (at week 7) and in an object recognition task (at weeks 7 and 8). CMS decreased sucrose intake, had an anxiogenic effect in the elevated plus maze, and impaired performance in the object recognition test. Imipramine, rivastigmine and donepezil normalized performance in all three tests. Memantine had anxiolytic and pro-cognitive effects, but did not reverse CMS-induced anhedon...Continue Reading

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Citations

Sep 7, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Clara Herrera-ArozamenaMaría Isabel Rodríguez-Franco
Jun 30, 2016·World Journal of Psychiatry·Francesca Demontis, Gino Serra
Jul 28, 2020·Translational Psychiatry·Paul J FitzgeraldBrendon O Watson
Apr 15, 2020·Pharmacology, Biochemistry, and Behavior·Murilo S de AbreuAllan V Kalueff
Mar 6, 2021·Frontiers in Behavioral Neuroscience·Ana Paula PesaricoJuan Nacher
Apr 29, 2021·Behavioural Brain Research·Paul J FitzgeraldBrendon O Watson
Jun 15, 2021·Frontiers in Behavioral Neuroscience·María Camila Acero-CastilloSilvia Botelho de Oliveira
Nov 27, 2019·Molecular Neuropsychiatry·Gislaine Zilli RéusJoão Quevedo

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