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Antidepressant drug administration modifies the interactive relationship between alpha(2)-adrenergic sensitivity and levels of TNF in the rat brain

Journal of Neuroimmunology

Jul 10, 2000

Tracey J NickolaRobert Nicholas Spengler

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Abstract

A reciprocally permissive interaction occurs between cellular responses elicited by the pleiotropic cytokine tumor necrosis factor-alpha (TNF) and alpha(2)-adrenergic receptor activation, such that each may adapt in response to modifications in the other's effects. Changes in presynapti...read more

Mentioned in this Paper

Zelmid
Desipramine
Adrenergic Receptor Agonist [EPC]
Structure of Locus Ceruleus
Norepinephrine, (+, -)-Isomer
Drug Kinetics
Metazoa
Brain
Rats, Holtzman
Entire Hippocampus
Paper Details
References
  • References20
  • Citations8
12
  • References20
  • Citations8
1

Antidepressant drug administration modifies the interactive relationship between alpha(2)-adrenergic sensitivity and levels of TNF in the rat brain

Journal of Neuroimmunology

Jul 10, 2000

Tracey J NickolaRobert Nicholas Spengler

PMID: 10808050

DOI: 10.1016/s0165-5728(00)00244-7

Abstract

A reciprocally permissive interaction occurs between cellular responses elicited by the pleiotropic cytokine tumor necrosis factor-alpha (TNF) and alpha(2)-adrenergic receptor activation, such that each may adapt in response to modifications in the other's effects. Changes in presynapti...read more

Mentioned in this Paper

Zelmid
Desipramine
Adrenergic Receptor Agonist [EPC]
Structure of Locus Ceruleus
Norepinephrine, (+, -)-Isomer

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Paper Details
References
  • References20
  • Citations8
12
  • References20
  • Citations8
1

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