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Antidepressant drug administration modifies the interactive relationship between alpha(2)-adrenergic sensitivity and levels of TNF in the rat brain

Journal of Neuroimmunology

May 16, 2000

T J NickolaRobert N Spengler

Abstract

A reciprocally permissive interaction occurs between cellular responses elicited by the pleiotropic cytokine tumor necrosis factor-alpha (TNF) and alpha(2)-adrenergic receptor activation, such that each may adapt in response to modifications in the other's effects. Changes in presynapti...read more

Mentioned in this Paper

Hippocampus (Brain)
Desipramine Measurement
Tumor Necrosis Factor-alpha
Autoreceptors
ratio-Desipramine
Structure of Locus Ceruleus
Human Activity Profile Test
Rats, Holtzman
Rat Brain
Antidepressive Agents
Paper Details
References
  • References20
  • Citations10
12
  • References20
  • Citations10
1

Antidepressant drug administration modifies the interactive relationship between alpha(2)-adrenergic sensitivity and levels of TNF in the rat brain

Journal of Neuroimmunology

May 16, 2000

T J NickolaRobert N Spengler

PMID: 10808050

DOI: 10.1016/s0165-5728(00)00244-7

Abstract

A reciprocally permissive interaction occurs between cellular responses elicited by the pleiotropic cytokine tumor necrosis factor-alpha (TNF) and alpha(2)-adrenergic receptor activation, such that each may adapt in response to modifications in the other's effects. Changes in presynapti...read more

Mentioned in this Paper

Hippocampus (Brain)
Desipramine Measurement
Tumor Necrosis Factor-alpha
Autoreceptors
ratio-Desipramine
Structure of Locus Ceruleus
Human Activity Profile Test
Rats, Holtzman
Rat Brain
Antidepressive Agents

Related Papers

Paper Details
References
  • References20
  • Citations10
12
  • References20
  • Citations10
1
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