PMID: 6105762May 1, 1980Paper

Antidepressant drugs in anergic schizophrenia. A double-blind cross-over study with maprotiline and placebo

Acta Psychiatrica Scandinavica
J Waehrens, J Gerlach

Abstract

Seventeen out of 20 inactive and emotionally withdrawn schizophrenic patients under long-term neuroleptic treatment completed a double-blind cross-over investigation of the possible activating effect of maprotiline, a relatively specific noradrenaline-reuptake inhibitor, compared with that of placebo. Each treatment phase lasted 8 weeks. No significant differences with respect to either the level of activity or schizophrenic symptoms were found between maprotiline (mean dose 138 mg/day) and placebo. Maprotiline provoked a slight psychotic exacerbation in one patient and sedation in another, four patients developed orthostatic hypotension, and two patients had an epileptic seizure. In the light of this and other studies, it must be concluded that antidepressant drugs do not represent any therapeutic advance in the treatment of inactive schizophrenic patients receiving neuroleptics.

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Citations

Jan 1, 1989·The Psychiatric Quarterly·S J Bartels, R E Drake
Jan 1, 1991·Progress in Neuro-psychopharmacology & Biological Psychiatry·S G SirisM A Shuwall
Mar 1, 1991·Pharmacopsychiatry·D Naber, H Hippius
Sep 3, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Surendra P SinghKelvin Chan
Jan 1, 2006·International Journal of Psychiatry in Clinical Practice·Prakash S MasandAshwin A Patkar
Sep 22, 2005·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Peter FalkaiUNKNOWN WFSBP Task Force on Treatment Guidelines for Schizophrenia
Nov 8, 2005·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Hans-Jürgen Möller
Mar 3, 2006·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Peter FalkaiUNKNOWN WFSBP Task Force on Treatment Guidelines for Schizophrenia
May 21, 2015·The International Journal of Neuropsychopharmacology·Viacheslav TerevnikovJan-Henry Stenberg
Jun 22, 2002·The Cochrane Database of Systematic Reviews·C WhiteheadG Lewis

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