PMID: 9522161Apr 2, 1998

Antidepressant drugs in the elderly

General Pharmacology
P GareriG De Sarro

Abstract

1. In this article some of the most important and tolerated drugs in the elderly are reviewed. 2. Tricyclic antidepressants have to be used carefully because of their important side effects. Nortriptyline and desipramine appear to be the best tolerated tricyclics in old people. 3. Second generation antidepressants are preferred for the elderly and those patients with heart disease as they have milder side effects and are less toxic in overdose. 4. MAO inhibitors are useful drugs in resistant forms of depression in which the above mentioned drugs have no efficacy and the last generation drugs (reversible MAO inhibitors), such as moclobemide, seem to be very successful. 5. Lithium is sometimes used especially to prevent recurrence of depression, even if its use is limited in old patients due to its side effects. 6. Psychotherapy is often used as an adjunct to pharmacotherapy, while electroconvulsant therapy is used only in the elderly patients with severe depression, high risk of suicide, or drug-resistant forms.

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Citations

Jun 25, 1999·Progress in Neurobiology·P GareriG De Sarro
Jun 2, 2009·Journal of Forensic and Legal Medicine·Ioannis StiakakisAristidis M Tsatsakis
Sep 2, 2008·Expert Opinion on Drug Safety·P GareriG De Sarro
Jan 5, 2000·Journal of Geriatric Psychiatry and Neurology·V AndreoliG Vantini
Jun 28, 2008·Drugs & Aging·Kara Zivin, Helen C Kales
May 31, 2007·Clinical Drug Investigation·P GareriG De Sarro
Jan 18, 2006·Journal of Speech, Language, and Hearing Research : JSLHR·James A HenryMartin A Schechter
Aug 9, 2003·Expert Opinion on Drug Safety·Barbara R SommerBen Flores

Related Concepts

Tricyclic Antidepressive Agents
Depressive Symptoms
Electroconvulsive Therapy
Heart Diseases
Resistance, Natural
Lithium
RIMA (Reversible Inhibitor of Monoamine Oxidase A)
Antidepressive Agents, Second-Generation

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