Antidepressant effect of repeated ketamine administration on kynurenine pathway metabolites in patients with unipolar and bipolar depression

Brain, Behavior, and Immunity
Yan-Ling ZhouYu-Ping Ning

Abstract

Ketamine has rapid antidepressant effects on treatment-resistant depression, but the biological mechanism underpinning this effect is less clear. Our aims were to examine whether kynurenine pathway metabolites were altered by six infusions of ketamine and whether these biological factors could act as potential biomarkers to predict ketamine's antidepressant effects. Six intravenous infusions of ketamine (0.5 mg/kg) were administered to 84 patients with unipolar and bipolar depression over a 12-d period. Symptom severity and response were assessed using the Montgomery-Asberg Scale (MADRS), and blood samples were collected at baseline and 24 h following the first infusion and at 24 h and 14 d after the sixth infusion (24 h, 13 d and 26 d). Blood samples from sixty healthy controls were collected for comparison with samples from the patients. Serum concentrations of tryptophan (TRP), kynurenine (KYN) and kynurenic acid (KYNA) were measured by the liquid chromatography-tandem mass spectrometry method. At baseline, serum levels of TRP and KYNA and the KYNA/KYN ratio were lower and the KYN/TRP ratio was greater in depressed patients than in healthy controls. Overall, fifty (59.5%) patients responded to ketamine at 13 d. Ketamine resp...Continue Reading

Citations

Dec 5, 2019·Current Psychiatry Reports·Aiste LengvenytePhilippe Courtet
Jul 29, 2020·Journal of Psychopharmacology·Yan-Ling ZhouYu-Ping Ning
Aug 17, 2019·Genes & Development·Niranjan VenkateswaranMaralice Conacci-Sorrell
Apr 14, 2019·Molecular Psychiatry·Jonathan Savitz
Oct 31, 2020·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Ather Muneer
Nov 7, 2018·Brain, Behavior, and Immunity·Andrew Harkin, Declan M McLoughlin
Dec 1, 2019·Current Behavioral Neuroscience Reports·Manivel RengasamyRebecca B Price
May 25, 2021·Neuroscience and Biobehavioral Reviews·Samara J BrownKelly A Newell
May 27, 2021·Therapeutic Advances in Psychopharmacology·Wei ZhengYu-Ping Ning
Jun 8, 2021·Frontiers in Immunology·Kaat HebbrechtManuel Morrens
Jun 29, 2021·Journal of Psychopharmacology·Emma KopraNaghmeh Nikkheslat
Jul 17, 2021·Biological Psychiatry·Timothy B Meier, Jonathan Savitz
Aug 13, 2021·Frontiers in Psychiatry·Peifen ZhangShaohua Hu

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