Antidepressant effects of dammarane sapogenins in chronic unpredictable mild stress-induced depressive mice

Phytotherapy Research : PTR
Ning JiangXin-Min Liu

Abstract

Depression is a common, dysthymic, and psychiatric disorder, resulting in enormous social and economic burden. Dammarane sapogenins (DS), an active fraction from oriental ginseng, has shown antidepressant-like effects in chronic restraint rats and sleep interruption-induced mice, and the present study aimed to further confirm the antidepressant effects of DS in a model of chronic unpredictable mild stress (CUMS) and to explore the underlying mechanism. Oral administration of DS (20, 40, and 80 mg/kg) markedly improved depressant-like behaviors, increasing the sucrose intake in the sucrose preference test and reducing the latency in the novelty-suppressed feeding test, and decreasing the immobility time in both the tail suspension and forced swimming tests, compared with the CUMS mice. Biochemical analysis of brain tissue and serum showed that DS treatment restored the decreased hippocampal neurotransmitter concentrations of serotonin, dopamine, norepinephrine (noradrenaline), and gamma-aminobutyric acid, and decreased the elevated of serum hormone levels (corticotrophin releasing factor, adrenocorticotrophic hormone, and corticosterone) induced by CUMS. Our findings confirm that DS exerts an antidepressant-like effect in the CU...Continue Reading

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Citations

Aug 24, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chao HongJianxin Wang
Dec 5, 2019·British Journal of Pharmacology·Elizabeth M WilliamsonAngelo A Izzo
Apr 9, 2020·Frontiers in Cellular Neuroscience·Wei HouRanji Cui
Oct 31, 2020·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Kyung Ho LeeChi-Un Pae
Nov 16, 2020·Journal of Ethnopharmacology·Mengjiao HeChunchao Han
Nov 19, 2020·Phytotherapy Research : PTR·Fatma Z SakhriMasataka Sunagawa

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