Antidepressant-like activity of a Kampo (Japanese herbal) medicine, Koso-san (Xiang-Su-San), and its mode of action via the hypothalamic-pituitary-adrenal axis

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
N ItoHaruki Yamada

Abstract

Koso-san (Xiang-Su-San in Chinese), a Kampo (Japanese herbal) medicine, is used clinically in East Asia for the treatment of depression-like symptoms associated with the initial stage of the common cold, allergic urticaria due to food ingestion, irritable bowel syndrome, chronic fatigue syndrome, insomnia, and autonomic imbalance. However, the antidepressant-like activity of Koso-san has never been evaluated scientifically. In this study, ddY mice subjected to a combination of forced swimming and chronic mild stresses were termed depression-like model mice. The degree of the depression-like state was measured by the animal's duration of immobility using the forced swimming test (FST). Oral administration of Koso-san (1.0 g/kg/body wt./day, 9 days) significantly shortened the duration of immobility of the depression-like model mice in the FST; however, locomotor activity was not affected. Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis plays an important role in the pathophysiology of depression. Levels of corticotropin-releasing hormone mRNA expression in the hypothalamus and proopiomelanocortin mRNA expression in the pituitary were significantly increased, and glucocorticoid receptor protein expression in the hy...Continue Reading

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Citations

Apr 22, 2010·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jun ZouJiaheng Tu
Dec 10, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Miho Igarashi, Yoshifumi Miyazaki
Jun 21, 2014·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Miho IgarashiYoshifumi Miyazaki
Dec 5, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Naoko KogaHiroyuki Kobayashi
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Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Rui ChenTsugiyasu Kanda
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Oct 21, 2016·Journal of Exercise Nutrition & Biochemistry·Na-Ri AhnHyuk-ki Chang

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