Antidepressant-like activity of the aqueous extract of Allium macrostemon in mice

Journal of Ethnopharmacology
Seungjoo LeeJong Hoon Ryu

Abstract

The aim of this study was to identify the effects of water extracts of Allium macrostemon Bunge (AM-W), a traditional herb, in mice. The antidepressant-like activities of AM-W were evaluated through behavioral despair in forced swimming test and tail suspension test. To elucidate the mode of action of the antidepressant-like effects of AM-W, new born cells in the subgranular zone and the granule cell layer were analyzed by immunostaining for incorporation of 5-bromo-2-deoxyuridine (BrdU). In addition, the effects of AM-W on the expression levels of brain-derived neurotrophic factor (BDNF) were investigated by western blotting and immunohistochemistry. The administration of AM-W reduced the immobility duration in the forced swimming test and tail suspension test (100 or 200 mg/kg, P<0.05). Sub-chronic administration of AM-W (100 or 200 mg/kg, p.o., for 14 days) increased the number of BrdU-incorporating cells. The percentage of BrdU-incorporating cells co-localized with NeuN was significantly increased after AM-W administration (100 or 200 mg/kg, P<0.05). Moreover, the expression levels of BDNF which is reported to be associated with neurogenesis were significantly increased in the hippocampus after administration of AM-W. These...Continue Reading

References

Jan 29, 1997·European Journal of Pharmacology·P SacerdoteA E Panerai
Jan 1, 1997·Molecular and Cellular Neurosciences·T D PalmerF H Gage
Feb 24, 2000·Phytotherapy Research : PTR·T K MaityM Pal
Jul 13, 2000·Journal of Psychopharmacology·S HjorthS B Auerbach
Oct 25, 2001·Proceedings of the National Academy of Sciences of the United States of America·B CzéhE Fuchs
Apr 4, 2002·Neuroreport·Andrea D E ZomkowskiAna Lúcia S Rodrigues
Oct 31, 2002·Human Psychopharmacology·M BourinF Clenet
Jun 5, 2003·European Journal of Pharmacology·Yun Feng LiJin Li
Aug 19, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Eliyahu DremencovMichael E Newman
Oct 24, 2003·The Journal of Comparative Neurology·Jason P BrownH Georg Kuhn
Nov 19, 2003·The Journal of Comparative Neurology·Golo KronenbergGerd Kempermann
Jul 24, 2004·Biological Psychiatry·Ronald S Duman
Jan 11, 2005·Current Pharmaceutical Design·Jessica E Malberg, Lee E Schechter
Jan 19, 2005·The European Journal of Neuroscience·Sebastien Couillard-DespresLudwig Aigner
Feb 4, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mikko SairanenEero Castrén
May 7, 2005·Metabolism: Clinical and Experimental·Madhu Kalia
May 22, 2007·CNS & Neurological Disorders Drug Targets·Michael R Drew, Rene Hen
Feb 8, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jing-Wen WangRené Hen
Sep 5, 2009·The Journal of Comparative Neurology·Benedetta LeunerElizabeth Gould

❮ Previous
Next ❯

Citations

Oct 11, 2015·Journal of Ethnopharmacology·Jee Hyun YiDong Hyun Kim
Jun 19, 2015·Pharmaceutical Biology·Nícolas de Castro Campos PintoElita Scio
Jul 26, 2012·Pharmaceutical Biology·Cheng-Xue JiJian-Jun Zhang
Dec 4, 2014·Journal of Natural Medicines·Dongmei DuanShuang Jiao
Sep 3, 2016·Journal of Asian Natural Products Research·Ayaka UsuiKanji Ishimaru
Feb 27, 2015·Reviews in the Neurosciences·Marzieh Sarbandi FarahaniRoja Rahimi
Feb 6, 2020·Current Pharmaceutical Design·Spyridon A PetropoulosNikos Tzortzakis
Nov 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hyung-Joong KimDonghun Lee
Jan 13, 2021·Planta medica·Inés Moragrega, José Luis Ríos
Aug 9, 2021·Journal of Ethnopharmacology·Xiaopei YangYunsheng Xu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Hai-Feng ChenXin-Sheng Yao
Progress in Neuro-psychopharmacology & Biological Psychiatry
Daniele G MachadoAna Lúcia S Rodrigues
© 2021 Meta ULC. All rights reserved