Antidepressant-Like Activity of the Ethanolic Extract from Uncaria lanosa Wallich var. appendiculata Ridsd in the Forced Swimming Test and in the Tail Suspension Test in Mice.

Evidence-based Complementary and Alternative Medicine : ECAM
Lieh-Ching HsuWen Huang Peng

Abstract

This study investigated the antidepressant activity of ethanolic extract of U. lanosa Wallich var. appendiculata Ridsd (UL(EtOH)) for two-weeks administrations by using FST and TST on mice. In order to understand the probable mechanism of antidepressant-like activity of UL(EtOH) in FST and TST, the researchers measured the levels of monoamines and monoamine oxidase activities in mice brain, and combined the antidepressant drugs (fluoxetine, imipramine, maprotiline, clorgyline, bupropion and ketanserin). Lastly, the researchers analyzed the content of RHY in the UL(EtOH). The results showed that UL(EtOH) exhibited antidepressant-like activity in FST and TST in mice. UL(EtOH) increased the levels of 5-HT and 5-HIAA in cortex, striatum, hippocampus, and hypothalamus, the levels of NE and MHPG in cortex and hippocampus, the level of NE in striatum, and the level of DOPAC in striatum. Two-week injection of IMI, CLO, FLU and KET enhanced the antidepressant-like activity of UL(EtOH). UL(EtOH) inhibited the activity of MAO-A. The amount of RHY in UL(EtOH) was 17.12 mg/g extract. Our findings support the view that UL(EtOH) exerts antidepressant-like activity. The antidepressant-like mechanism of UL(EtOH) may be related to the increase i...Continue Reading

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Citations

Jan 21, 2014·Journal of Ethnopharmacology·Guang Yue SuChun Fu Wu
Nov 15, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Mahmoud Ben OthmanHiroko Isoda
Nov 18, 2015·Journal of Ethnobiology and Ethnomedicine·Michael KochPrem P Rai
Jun 21, 2015·Journal of Ethnopharmacology·Qian ZhangWei Qu
Jun 20, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Li-Tao YiXiao-Hong Wang
Nov 16, 2012·Journal of Psychopharmacology·Li-Tao YiLian-Jin Weng
Nov 29, 2017·BMC Complementary and Alternative Medicine·Harquin Simplice FoyetAlin Ciobica
Feb 27, 2015·Reviews in the Neurosciences·Marzieh Sarbandi FarahaniRoja Rahimi

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