Antidepressant-like effect of centrally acting non-narcotic antitussive caramiphen in a forced swimming test

Neuroscience Letters
Kazuaki KawauraKazuo Takahama

Abstract

Recently, we reported that a centrally acting non-narcotic antitussive (cough suppressant drug), tipepidine produces an antidepressant-like effect in the forced swimming test in rats. Because pharmacological properties of tipepidine apparently differ from those of typical antidepressants developed to date, we speculated that caramiphen, another centrally acting antitussive, has an antidepressant-like effect. That effect of caramiphen was studied in rats using the forced swimming test. Caramiphen at 20 and 40mg/kg i.p. significantly reduced immobility. At 40mg/kg i.p., it increased climbing behavior. Even at 40mg/kg, this drug had no effect on locomotor activity. Results suggest that a centrally acting antitussive possessing inhibition of GIRK channels has an antidepressant-like effect.

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Citations

Feb 20, 2016·Pharmacology, Biochemistry, and Behavior·Fumio SoedaKazuo Takahama
Oct 15, 2011·Behavioural Brain Research·Kazuaki KawauraKazuo Takahama
Dec 3, 2014·European Journal of Pharmacology·Yuk-Man LeungJhi-Joung Wang
Oct 9, 2012·The International Journal of Neuropsychopharmacology·María TorrecillaLuisa Ugedo

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