PMID: 20703010Aug 13, 2010

Antidepressant-like effect of venlafaxine is abolished in μ-opioid receptor-knockout mice

Journal of Pharmacological Sciences
Soichiro IdeKumatoshi Ishihara


Although the opioid system is known to modulate depression-like behaviors, its role in the effects of antidepressants is not yet clear. We investigated the role of μ-opioid receptors (MOPs) in the effects of venlafaxine, a serotonin and norepinephrine reuptake inhibitor, in the forced swim test using MOP-knockout (KO) mice. Venlafaxine reduced immobility time in wild-type mice (C57BL/6J), but not in MOP-KO mice, although no significant effects were observed on locomotor activity. These results suggest that MOPs play an important role in the antidepressant-like effects of venlafaxine.


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Related Concepts

Antidepressive Agents, Second-Generation
Morpholinopropane sulfonic acid
Receptors, Opioid, mu
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Depressive Symptoms
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