PMID: 20703010Aug 13, 2010

Antidepressant-like effect of venlafaxine is abolished in μ-opioid receptor-knockout mice

Journal of Pharmacological Sciences
Soichiro IdeKumatoshi Ishihara

Abstract

Although the opioid system is known to modulate depression-like behaviors, its role in the effects of antidepressants is not yet clear. We investigated the role of μ-opioid receptors (MOPs) in the effects of venlafaxine, a serotonin and norepinephrine reuptake inhibitor, in the forced swim test using MOP-knockout (KO) mice. Venlafaxine reduced immobility time in wild-type mice (C57BL/6J), but not in MOP-KO mice, although no significant effects were observed on locomotor activity. These results suggest that MOPs play an important role in the antidepressant-like effects of venlafaxine.

References

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Aug 16, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Pegah KhalooAhmad-Reza Dehpour
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Dec 30, 2016·The International Journal of Neuropsychopharmacology·Soichiro IdeKazutaka Ikeda
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Citations

Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·Ichiro SoraGeorge R Uhl
Nov 24, 1999·Biological Psychiatry·E J NestlerG K Aghajanian
May 30, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ichiro SoraGeorge R Uhl
May 15, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniel C BroomJames H Woods
Mar 22, 2003·The Journal of Pharmacology and Experimental Therapeutics·Stephen D MagueWilliam A Carlezon
Jul 11, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jakub FichnaJean-Claude do Rego
Apr 14, 2007·The Journal of Pharmacology and Experimental Therapeutics·Esther Berrocoso, Juan Antonio Mico
Jul 15, 2009·Neuropharmacology·Soichiro IdeKumatoshi Ishihara

Related Concepts

Swimming
Cyclohexanol
Antidepressive Agents, Second-Generation
Morpholinopropane sulfonic acid
Receptors, Opioid, mu
Mice, Knockout
Depressive Symptoms
Antidepressant Measurement
Antidepressive Agents
Mice, Inbred C57BL

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