Antidepressant-like effects of 1-aminocyclopropanecarboxylic acid and D-cycloserine in an animal model of depression

European Journal of Pharmacology
M Papp, E Moryl

Abstract

Antidepressant activity of partial agonists at strychnine-insensitive glycine receptors, 1-aminocyclopropanecarboxylic acid (ACPC) and D-cycloserine, was studied in a chronic mild stress model of depression. In this model, a substantial decrease in consumption of a palatable sucrose solution is observed over time in rats subjected to a variety of mild stressors. This decrement can be reversed by chronic administration of antidepressant drugs. Chronic (5 weeks) treatment with ACPC gradually reversed chronic mild stress-induced reductions in sucrose consumption, and the magnitude of this effect was comparable to that observed following similar administration of imipramine (10 mg/kg). The time-course for reversal of chronic mild stress-induced deficits in sucrose consumption by ACPC was dose-dependent. Thus, the first statistically significant effect of the low dose of ACPC (100 mg/kg) was observed after four weeks of treatment (comparable to the 3-5 weeks required for imipramine), while only two weeks of treatment was required in the group receiving a higher dose (200 mg/kg) of ACPC. Like imipramine, reversal of chronic mild stress-induced deficits in sucrose consumption by ACPC persisted for at least one week following cessation...Continue Reading

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Citations

Feb 24, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Asher B Simon, Jack M Gorman
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