Antidepressant Mechanism Research of Acupuncture: Insights from a Genome-Wide Transcriptome Analysis of Frontal Cortex in Rats with Chronic Restraint Stress

Evidence-based Complementary and Alternative Medicine : ECAM
Yu WangTuya Bao

Abstract

Major depressive disorder (MDD) is a chronic disease that adversely affects mood and cognition. In this study, we randomly divided the rats into control group (C), model group (M), fluoxetine group (F), and acupuncture group (A), used open-field test to ascertain whether acupuncture affects chronic restraint stress (CRS) induced depression-like behaviors of rats, and explored the antidepressant mechanism of acupuncture at the molecular level of transcriptome in the frontal cortex of CRS rats by RNA-sequencing (RNA-seq). According to differentially expressed genes (DEG) analysis, we identified 134, 46, and 89 response genes differentially expressed in C versus M, F versus M, and A versus M, respectively. Through Gene Ontology (GO) term enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, we identified the gene sets involved in extracellular space, inflammatory response, Toll-like receptor signaling pathway, chemokine signaling pathway, and TNF signaling pathway. In this study, RNA-seq technology was used to investigate the frontal cortex genome-wide transcriptomes in depression rats under CRS, which suggested that the antidepressant effect of acupuncture is effective and has a multi...Continue Reading

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Citations

Jul 8, 2020·International Journal of Molecular Sciences·Tzu-Hsuan Wei, Ching-Liang Hsieh
Jul 1, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Dan LuoRui Chen
Aug 3, 2019·Journal of Clinical Medicine·Mike ArmourPhillipa Hay
Aug 6, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Hsiang-Chun LaiChing-Liang Hsieh

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Datasets Mentioned

BETA
GSE86392

Methods Mentioned

BETA
RNA-seq
Dissection
electrophoresis
PCR

Software Mentioned

Java Tree View
FastQC
DAVID Functional Annotation Tool
Ensembl
edgeR
FASTX
TopHat2
SPSS
- Toolkit

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