Antidepressant medication and executive dysfunction: a deleterious interaction in late-life depression.

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
Joel R SneedSteven P Roose

Abstract

To determine whether there is differential response to placebo or citalopram among older patients with and without deficient response inhibition (DRI). This is an 8-week, double-blind, placebo-controlled trial. Outpatient psychiatry. Unipolar depressed patients aged 75 years and older. Citalopram (20-40 mg/day) or placebo pill. Baseline Stroop Color-Word Test and weekly 24-item Hamilton Rating Scale for Depression assessments. Citalopram-treated patients with DRI did significantly worse than placebo-treated patients with DRI. Conversely, citalopram-treated patients without DRI did significantly better than placebo-treated patients without DRI. Patients with late-life depression and DRI respond worse to selective serotonin reuptake inhibitor (SSRI) than placebo. These findings suggest that there may be a deleterious interaction between DRI and antidepressant medication in late-life depression and that the mechanism of SSRI and placebo response is different.

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Citations

Feb 13, 2016·Zeitschrift für Gerontologie und Geriatrie·Dirk K Wolter
Nov 16, 2013·The Psychiatric Clinics of North America·Sarah Shizuko Morimoto, George S Alexopoulos
Apr 10, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Patrick J BrownSteven P Roose
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