Antidepressant Prescription Claims Among Reproductive-Aged Women With Private Employer-Sponsored Insurance - United States 2008-2013

MMWR. Morbidity and Mortality Weekly Report
April L DawsonMargaret A Honein

Abstract

Antidepressant medication use during pregnancy has been increasing in the United States (1). Many women require antidepressants on an ongoing basis, and a clear consensus on the safest medication options for both the mother and her fetus does not exist (2). Given that half of all U.S. pregnancies are unplanned (3), antidepressant use will occur during the first weeks of pregnancy, a critical period for fetal development. To understand trends among women of reproductive age, CDC used Truven Health's MarketScan Commercial Claims and Encounters data* to estimate the number of antidepressant prescriptions filled by women aged 15-44 years with private employer-sponsored insurance. During 2008-2013, an average of 15.4% of women aged 15-44 years filled at least one prescription for an antidepressant in a single year. The most frequently filled antidepressants included sertraline, bupropion, and citalopram. Prescribing of antidepressants is common, and research on antidepressant safety during pregnancy needs to be accelerated to provide evidence-based information to health care providers and women about the potential risks for antidepressant exposure before and during pregnancy and between pregnancies.

References

Sep 8, 2010·American Journal of Obstetrics and Gynecology·Sherry L FarrPatricia M Dietz
Feb 5, 2013·General Hospital Psychiatry·Krista F HuybrechtsSonia Hernández-Díaz
Dec 21, 2013·American Journal of Public Health·Lawrence B Finer, Mia R Zolna
Jul 9, 2014·Obstetrics and Gynecology·Marian S McDonaghJeanne-Marie Guise
Apr 22, 2015·Annals of Epidemiology·Elizabeth T JensenEvan S Dellon
Jul 15, 2015·BMJ : British Medical Journal·Jennita ReefhuisUNKNOWN National Birth Defects Prevention Study
Jan 28, 2016·JAMA : the Journal of the American Medical Association·Albert L SiuMichael P Pignone

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Citations

Dec 4, 2009·PloS One·Vernon J LeeMark I-Cheng Chen
Sep 7, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jenna L N SprowlesCharles V Vorhees
Nov 29, 2016·Birth Defects Research. Part A, Clinical and Molecular Teratology·Elizabeth C AilesSuzanne M Gilboa
Sep 8, 2018·Depression and Anxiety·Marlene P FreemanLee S Cohen
Sep 21, 2016·Journal of Psychiatric Practice·Yuanjia ZhuXavier F Jimenez
Apr 13, 2017·Reproductive Sciences·Kristin PalmstenGermaine M Buck Louis
Aug 5, 2017·Frontiers in Pharmacology·Anick BérardUNKNOWN OTIS (MotherToBaby) Collaborative Research Committee
May 22, 2020·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Elizabeth Wall-WielerSuzan L Carmichael
Jan 25, 2019·Harvard Review of Psychiatry·Christie SylvesterPriya Gopalan
Mar 2, 2021·The American Journal of Psychiatry·Kimberly A Yonkers
Apr 7, 2021·Molecular Psychiatry·Zeljka KoradeKároly Mirnics
Apr 17, 2021·ACS Pharmacology & Translational Science·Thiago C Genaro-MattosKároly Mirnics
Sep 7, 2021·Human Reproduction·Rita RahbanSerge Nef
Apr 6, 2021·Therapeutic Drug Monitoring·Emily E FayNina Isoherranen

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