Abstract
Depression is a predictor of poor prognosis in patients with heart failure. Selective serotonin (5-HT) reuptake inhibitors (SSRIs) may improve these outcomes. Left ventricular volume overload induced hypertrophy that is associated with aortic regurgitation (AR) leads to ventricular dysfunction and heart failure. The aim of this study was to verify the effects of the SSRI paroxetine on cardiac function, as well as on fluid intake and excretion, in subchronic AR. Male Wistar rats (260 to 280g) received sham (SH) surgery or AR induced by retrograde puncture of the aortic valve leaflets. The presence of AR was confirmed by echocardiography (ECHO) exams. Four weeks after AR surgery, subcutaneous injections of paroxetine (PAR: 10mg/kg 3 times in a week) or saline were administered. The rats were randomly divided into the following 4 groups and treated for 4 weeks: AR-PAR, ARsaline, SH-PAR and SH-saline. At the end of the treatment period, fractional shortening was preserved in AR-PAR, compared to AR-saline (46.6±2.7% vs 38.3±2.2%, respectively). Daily 0.3 M NaCl intake was reduced in PAR-treated rats. Natriuresis was increased in weeks 2-3 after PAR treatment. Our results suggest that augmentation of central 5-HT neurotransmission ha...Continue Reading
References
Jun 1, 1978·The Journal of Comparative Neurology·E C Azmitia, M Segal
Oct 8, 1997·Journal of Clinical Psychopharmacology·P TuckerH McLean
Feb 5, 1998·JAMA : the Journal of the American Medical Association·S P RooseI Gergel
Mar 29, 2001·Journal of Clinical Psychopharmacology·F LederbogenM Deuschle
Oct 2, 2001·American Heart Journal·A McFarlaneG Norman
Mar 30, 2004·Anais Da Academia Brasileira De Ciências·Hawlinston R C LimaLuís C Reis
Jul 6, 2005·Archives of General Psychiatry·C Barr TaylorUNKNOWN ENRICHD Investigators
Jul 8, 2005·Psychopharmacology·Michael GoldingJ C Garbutt
Sep 13, 2005·Biological Psychiatry·Angela J GrippoAlan Kim Johnson
Nov 1, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·H R Cavalcante-LimaL C Reis
Jan 20, 2007·International Journal of Geriatric Psychiatry·Koen Van der KooyAartjan Beekman
Apr 1, 2008·Cardiology·Trudie C Somberg, Rohit R Arora
Oct 14, 2008·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Katherine R Beich, Clyde Yancy
Jan 1, 2009·Stress : the International Journal on the Biology of Stress·Angela J Grippo, Alan Kim Johnson
May 6, 2009·Psychosomatic Medicine·Carmilla M M LichtBrenda W J H Penninx
May 4, 2010·Mayo Clinic Proceedings·Kameswari MagantiRobert O Bonow
Sep 8, 2010·Autonomic Neuroscience : Basic & Clinical·Lilia S Urzedo-RodriguesJosmara B Fregoneze