Antidepressant treatment history and drug-placebo separation in a placebo-controlled trial in major depressive disorder

Psychopharmacology
Aimee M HunterAndrew F Leuchter

Abstract

A history of antidepressant treatment may predispose subjects toward placebo nonresponse in randomized controlled trials (RCTs) in major depressive disorder (MDD). The objective of this study is to examine self-reported prior antidepressant treatment and response in relationship to clinical outcome in an 8-week randomized trial of reuptake inhibitor antidepressant medication (MED) versus placebo (PBO) administered along with limited supportive care. Chi-square and MMRM analyses examined MED vs. PBO outcomes in antidepressant-naïve vs. antidepressant-experienced subjects. Linear regression models examined treatment history along with covariates as predictors of clinical improvement. Among completers (n = 56), there was no significant difference in response rate between MED (53.3 %) and PBO (42.3 %) (χ (2) = 0.33, p = 0.28, 1-tailed). The antidepressant-experienced subgroup (n = 37), however, showed a significantly greater response rate to MED (52.4 %) than PBO (25.0 %) (χ (2) = 2.82, p = 0.047, 1-tailed). The full intent-to-treat (ITT) sample (n = 69) did not show a significant difference between MED and PBO group improvement over time, but in the treatment-experienced subgroup (n = 46), MED showed significantly greater improvem...Continue Reading

References

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Citations

Aug 20, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Jonathan H HsuDaniel M Blumberger
Dec 3, 2015·The British Journal of Psychiatry : the Journal of Mental Science·Andrew F LeuchterIan A Cook
Jun 9, 2017·Science Translational Medicine·Matthias ZunhammerUlrike Bingel
Jun 30, 2019·Frontiers in Psychiatry·Irving Kirsch

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